TY - JOUR AU - H, Syahputri AU - J, Silalahi AU - U, Harahap AU - D, Satria PY - 2020/08/15 Y2 - 2024/03/28 TI - Antidiabetic Activity of Lactobacillus fermentum Bacteria from Dengke Naniura Goldfish (Cyprinuscarpio) in Nicotinamide-Streptozotosin Induced Rats JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 8 IS - 4 SE - Research Articles DO - 10.22270/ajprd.v8i4.778 UR - https://ajprd.com/index.php/journal/article/view/778 SP - 12-15 AB - <p><strong>Objectives:</strong> This study aims to determine the effect of <em>Lactobacillus fermentum</em> on decreasing blood glucose levels, sRAGE, HbA1c levels.Methods: Testing was done on male rats, which consisted of 7 groups. Group 1 as negative control was given Na-CMC0.5%, group 2 was given <em>Lactobacillus fermentum</em> isolate dose 0.5mL, group 3 was given <em>Lactobacillus fermentum</em> isolate dose 1mL, group 4 was given <em>Lactobacillus fermentum</em> isolate dose 1.5mL, group 5 was given <em>Lactobacillus fermentum</em> isolate dose 2 mL, group 6 as positive control was given glibenclamide dose 0.45 mg/kg, and group 7 as the normal group. Decreased KGD, sRAGE, HbA1C.<strong>Results:</strong> The results of statistical analysis showed that the administration of <em>Lactobacillus fermentum </em>showed the effect of a decrease in blood glucose (KGD) rats that were not significantly different than the positive control group (p &lt;0.05). From the results of testing the <em>Lactobacillus fermentum</em> 2 mL treatment group gave the best results on decreasing sRAGE levels; decreased HbA1C.<strong>Conclusion:</strong> Based on the results of this study <em>Lactobacillus fermentum</em> bacteria can reduce blood glucose, sRAGE, HbA1C levels in rats induced by Nicotinamide-Streptozotosin.</p><p>&nbsp;</p> ER -