TY - JOUR AU - Karima, Nurul AU - Sumaiyah, Sumaiyah AU - Nasution, Azizah PY - 2020/02/15 Y2 - 2024/03/29 TI - Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 8 IS - 1 SE - Research Articles DO - 10.22270/ajprd.v8i1.644 UR - https://ajprd.com/index.php/journal/article/view/644 SP - 11-13 AB - <p><strong>Objectives:</strong> To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.</p><p><strong>Interventions:</strong> Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.</p><p><strong>Main outcomes measure:</strong> The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.</p><p><strong>Conclusion:</strong> There was no significant cumulative percent drug release difference (p&gt; 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.</p><p><strong>&nbsp;</strong></p><p>&nbsp;</p> ER -