TY - JOUR AU - Dzakwan, Muhammad AU - Ganet, Eko Pramukantoro AU - Rachmat, Mauludin AU - Wikarsa, Saleh PY - 2019/04/15 Y2 - 2024/03/28 TI - Nanosized and Enhancement of Solubility Fisetin JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 7 IS - 2 SE - Research Articles DO - 10.22270/ajprd.v7i2.465 UR - https://ajprd.com/index.php/journal/article/view/465 SP - 6-10 AB - <p>Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidant that has shown to posses anticancer, antioxidant and anti-inflammatory properties. However, the poor solubility leads to poor bioavailability and limits its development.The aim of the research is to investigate the effect of fisetin nanosuspension using a nanoprecipitation technique and additional stabilizers polysorbat 80, SLS, PVA and Eudragit on particle size average, polydispersity index and zeta potential.The suspensions of microcrystalline FIS were prepared by a nanoprecipitation technique with different proportion of stabilizers fixed. The nanosuspension produced was then characterized using Photon Correlation Spectroscopy (PCS) in&nbsp; term of particle size distribution, polydispersity index, zeta potential and morphology nanosuspensiom (TEM). Result showed fisetin nanosuspension were successfully prepared by anti-solvent precipitation with additional stabilizer SLS and polysorbat 80. The nanosuspension containing polysorbat 80 showed smaller average particle size of 225.7 nm ± 1.31, a polydispersity index of 0.272 ±0.02 and zeta potential -39.3 ± 0.26 was obtained. Conclusion, FIS nanosuspension successfully prepared by nanoprecipitation tecnique with the polysorbate 80 as stabilizer and ethanol as solvent were spherical in shape..</p> ER -