@article{Sasmita_K_Aminah_2021, title={The Evaluation of Rationality of Medicines Use in Terms of Prescribing Indicators At The Health Center (Puskesmas) Serdang Bedagai District In 2019}, volume={9}, url={https://ajprd.com/index.php/journal/article/view/923}, DOI={10.22270/ajprd.v9i1.923}, abstractNote={<p><strong>Objective:</strong> The aim of this study was to determine the effectiveness of aloe vera gel in inhibiting skin aging.</p> <p><strong>Method:</strong> The powder was extracted with ethanol in macerated method. Extract ethanol were analyzed for antioxidant activity with DPPH assay. <em>Aloe vera</em> extract that has been obtained then made variations of different extract concentrations namely 3% and 6% based on the orientation of researchers to determine the concentration, then in the formulation into gel. Anti-aging activity testing using skin analyzer tools with moisture parameters, collagen levels, pore, sensitivity before and after exposure to UV A and UV B rays.</p> <p><strong>Results:</strong> IC<sub>50</sub> value of aloe vera extract obtained by 138.65 ppm. Based on the classification of antioxidant activity shows that IC<sub>50</sub> value of aloe vera extract has moderate antioxidants that range from 101 to 250 ppm. The percentage of moisture content in week I to week IV, F3 has an increase of 26% i.e week 1 is 4% and week IV is 30%. The percentage of collagen levels in week I to week IV, F3 has an increase of 50% i.e week 1 is 30% and week IV is 80%. Increase in the percentage of elasticity in the week I to week IV. F3 had the highest increase of 25%, in week 1 it was 50% and week IV was 75%. A large decrease in pores occurs in weeks I through week IV. F3 had the highest decrease of 0.06 mm, in the week I was 0.07 mm and week IV was 0.01 mm.</p> <p><strong>Conclusion:</strong> Aloe vera extract gel preparation has activity as a rejuvenation agent at a concentration of 6%.</p> <p> </p>}, number={1}, journal={Asian Journal of Pharmaceutical Research and Development}, author={Sasmita, Irawati and K, Khairunnisa and Aminah, Dalimunthe}, year={2021}, month={Feb.}, pages={51–56} }