@article{Kiumarsi_Hesabi_Tavanayan_Amirkashani_Azarkeivan_Molavi_2020, title={Effect of L-carnitine on sperm parameters in patients with Thalassemia major: A pilot study}, volume={8}, url={https://ajprd.com/index.php/journal/article/view/820}, DOI={10.22270/ajprd.v8i5.820}, abstractNote={<p><strong>Background:</strong> More than one-half of men with transfusion dependent thalassemia major (TDTM) are dealing with decreased fertility potentials. As antioxidants such as L-carnitine were reported to improve fertility in healthy males, we aimed to assay the effect of L-carnitine on sperm parameters in adult males with TDTM.</p> <p><strong>Materials and Methods:</strong> Twenty six male TDTM patients older than 18 years were included in a pilot study, all had semen analysis; 3 were found to be azoospermic and were excluded. So further analysis for sperms and DNA defects was conducted on the remaining 10 participants. Participants were then given L-carnitine for 3 months. All sperm parameters were reassessed after therapy.</p> <p><strong>Results:</strong> In patients with low volume ejaculation, the mean volume of semen increased significantly (p=0.034). In oligospermic patients with a mean sperm concentration of 4.62 million/mL, the mean sperm concentration raised to 22.50 million/mL after therapy (p=0.008). In patients who had lower than normal sperm motility percentage and sperm progressive motility percentage, both variables raised after therapy.</p> <p><strong>Conclusion:</strong> Thalassemia major patients showed significant increase in sperm concentration and sperm motility with the use of L-carnitine.</p> <p> </p>}, number={5}, journal={Asian Journal of Pharmaceutical Research and Development}, author={Kiumarsi, Azadeh and Hesabi, Amir and Tavanayan, Masoumeh and Amirkashani, Davoud and Azarkeivan, Azita and Molavi, Mohammad Ali}, year={2020}, month={Oct.}, pages={14–17} }