@article{Singh_Parle_2020, title={Synthesis, Characterization and Antioxidant Activity of 2-Aryl Benzimidazole Derivatives}, volume={8}, url={https://ajprd.com/index.php/journal/article/view/582}, DOI={10.22270/ajprd.v8i2.582}, abstractNote={<p><strong>Objective:</strong> To synthesize benzimidazole derivatives, characterize them by <sup>1</sup>HNMR and ATIR techniques and evaluate their antioxidant activity.</p> <p><strong>Methods:</strong> In the present study 19 benzimidazole derivatives were synthesized by reacting <em>O</em>-phenylenediamine as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatography technique, and the newly synthesized derivatives were characterized by ATIR and <sup>1</sup>HNMR techniques. The antioxidant assay was performed using ABTS [2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)] method and DPPH [2,2-diphenyl-1-picrylhydrazyl] method.</p> <p><strong>Results:</strong> Compounds BNZ-1, BNZ-2, BNZ-3, BNZ-9, and BNZ-10 showed comparable antioxidant activity to ascorbic acid at higher dose.</p> <p><strong>Conclusion: T</strong>he synthesized benzimidazole derivatives have significant radical scavenging potential.</p> <p><strong> </strong></p> <p> </p>}, number={2}, journal={Asian Journal of Pharmaceutical Research and Development}, author={Singh, Vineet Kumar and Parle, Amrita}, year={2020}, month={Apr.}, pages={35–44} }