Dendrimers: Potential Drug Carrier For Novel Drug Delivery System
DOI:
https://doi.org/10.22270/ajprd.v9i2.945Keywords:
Dendrimer, PAMAM (Poly Amido Amine) Dendrimer, PAMAMOS (Poly Amidoamine Organosilicon) Dendrimers, PPI (Poly Propylene Imine) DendrimerAbstract
Dendrimers are new effectiveness of polymeric substances. They are relatively branched, monodisperse macromolecules. Structural Advantages permit dendrimers to play a critical function inside the fields of nanotechnology, pharmaceutical, and medicinal chemistry. As a result in their precise behavior dendrimers are suitable for a wide variety of biomedical and commercial packages. The paper gives a quick evaluation of dendrimers’ physicochemical properties and their possible use in various regions of research, generation, and treatment.
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References
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2. Vogtle F, Buhleier E, Wehner W. Cascade and nonskid-chain-like syntheses of molecular cavity topologies. Synthesis. 1978;2:155-8.
3. Dwivedi DK, Singh AK. Dendrimers: A novel carrier system for drug delivery. Journal of Drug Delivery and Therapeutics. 2014;4(5):1-6.
4. Kumar P, Meena K, Kumar P, Choudhary C, Thakur DS, Bajpayee P. Dendrimer: a novel polymer for drug delivery. JITPS. 2010;1(6):252-69.
5. Tomalia DA. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Progress in Polymer Science. 2005;30(3-4):294-324.
6. Baig T, Nayak J, Dwivedi V, Singh A, Srivastava A, Tripathi PK. A review about dendrimers: synthesis, types, characterization and applications. Int J Adv Pharm Biol Chem. 2015;4:44-59.
7. Sakthivel T, Florence A. Adsorption of amphipathic dendrons on polystyrene nanoparticles. International journal of pharmaceutics. 2003;254(1):23-6.
8. Klajnert B, Bryszewska M. Dendrimers: properties and applications. Acta biochimica polonica. 2001;48(1):199-208.
9. Buhleier E. " cascade"-and" nonskid-chain-like" syntheses of molecular cavity topologies. 1978.
10. Boas U, Christensen JD, Christensen JB, Heegaard P. Dendrimers in medicine and biotechnology: new molecular tools: Royal Society of Chemistry; 2006.
11. Svenson S, Tomalia DA. Dendrimers in biomedical applications—reflections on the field. Advanced drug delivery reviews. 2012;64:102-15.
12. Patri AK, Majoros IJ, Baker Jr JR. Dendritic polymer macromolecular carriers for drug delivery. Current opinion in chemical biology. 2002;6(4):466-71.
13. Dufes C, Uchegbu IF, Schätzlein AG. Dendrimers in gene delivery. Advanced drug delivery reviews. 2005;57(15):2177-202.
14. Pushkar S, Philip A, Pathak K, Pathak D. Dendrimers: Nanotechnology derived novel polymers in drug delivery. Indian Journal of Pharmaceutical Education and Research. 2006;40(3):153.
15. Jain N, Khopade A. Dendrimers as potential delivery systems for bioactives. Advances in controlled and novel drug delivery. 2001:369-80.
16. Patel R. Dendrimers: A new innovation in drug delivery. Pharma Bio World. 2007;1:42-52.
17. Patidar A, Thakur D. Dendrimers: As a potential carrier for medicaments. IJPLS. 2010;1(2):91-8.
18. Barbara K, Maria B. Review Dendrimers: properties and applications. Acta biochimica polonica. 2001;48(1):199-208.
19. Hawker C, Fréchet JM. A new convergent approach to monodisperse dendritic macromolecules. Journal of the Chemical Society, Chemical Communications. 1990(15):1010-3.
20. Crampton HL, Simanek EE. Dendrimers as drug delivery vehicles: non‐covalent interactions of bioactive compounds with dendrimers. Polymer international. 2007;56(4):489-96.
21. Dhadwal A, Sharma DR, Pandit V, Ashawat MS, Kumar P. Cubosomes: A Novel Carrier for Transdermal Drug Delivery. Journal of Drug Delivery and Therapeutics. 2020;10(1):123-30.
22. Nanjwade BK, Bechra HM, Derkar GK, Manvi F, Nanjwade VK. Dendrimers: emerging polymers for drug-delivery systems. European Journal of Pharmaceutical Sciences. 2009;38(3):185-96.
23. Gillies ER, Frechet JM. Dendrimers and dendritic polymers in drug delivery. Drug discovery today. 2005;10(1):35-43.
24. Tolia GT, Choi HH. The role of dendrimers in topical drug delivery. Pharmaceutical technology. 2008;32(11):88-98.
25. Gupta U, Agashe HB, Jain NK. Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes. J Pharm Pharm Sci. 2007;10(3):358-67.
26. Wang D, Imae T. Fluorescence emission from dendrimers and its pH dependence. Journal of the American Chemical Society. 2004;126(41):13204-5.
27. Chai M, Niu Y, Youngs WJ, Rinaldi PL. Structure and conformation of DAB dendrimers in solution via multidimensional NMR techniques. Journal of the American Chemical Society. 2001;123(20):4670-8.
28. Tripathy S, Das MK. Dendrimers and their applications as novel drug delivery carriers. J Appl Pharm Sci. 2013;3(09):142-9.
29. Hawker CJ, Frechet JM. Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. Journal of the American Chemical Society. 1990;112(21):7638-47.
30. Akki R, Ramya MG, Sadhika C, Spandana D. A novel approach in drug delivery system using dendrimers. 2019.
31. Shinde G, Bangale G, Umalkar D, Rathinaraj B, Yadav C, Yadav P. Dendrimers. J Pharm Biomed Sci. 2010;3(03):1-8.
32. Esfand R, Tomalia DA. Poly (amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug discovery today. 2001;6(8):427-36.
33. Schiavon O, Pasut G, Moro S, Orsolini P, Guiotto A, Veronese F. PEG–Ara-C conjugates for controlled release. European journal of medicinal chemistry. 2004;39(2):123-33.
34. Braña MF, Domı́nguez G, Sáez B, Romerdahl C, Robinson S, Barlozzari T. Synthesis and antitumour activity of new dendritic polyamines–(imide–DNA-intercalator) conjugates: potent Lck inhibitors. European journal of medicinal chemistry. 2002;37(7):541-51.
35. Cheng Y, Xu Z, Ma M, Xu T. Dendrimers as drug carriers: applications in different routes of drug administration. Journal of pharmaceutical sciences. 2008;97(1):123-43.
36. Yiyun C, Zhenhua X, Minglu M, Tonguen X. Dendrimers as drug carriers: applications in different routes of drug. J Pharma Sci. 2008;97(1):123-43.
37. Brownlie A, Uchegbu I, Schätzlein A. PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. International journal of pharmaceutics. 2004;274(1-2):41-52.
38. Liu M, Kono K, Fréchet JM. Water-soluble dendritic unimolecular micelles:: Their potential as drug delivery agents. Journal of Controlled Release. 2000;65(1-2):121-31.
39. Medina SH, El-Sayed ME. Dendrimers as carriers for delivery of chemotherapeutic agents. Chemical reviews. 2009;109(7):3141-57.
40. Neerman MF, Zhang W, Parrish AR, Simanek EE. In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery. International journal of pharmaceutics. 2004;281(1-2):129-32.
41. Krause W, Hackmann-Schlichter N, Maier FK, Müller R. Dendrimers in diagnostics. Dendrimers II: Springer; 2000. p. 261-308.
42. Achar S, Puddephatt RJ. Organoplatinum dendrimers formed by oxidative addition. Angewandte Chemie International Edition in English. 1994;33(8):847-9.
43. Miller LL, Duan RG, Tully DC, Tomalia DA. Electrically conducting dendrimers. Journal of the American Chemical Society. 1997;119(5):1005-10.
44. Wilken R, Adams J. End‐group dynamics of fluorescently labeled dendrimers. Macromolecular rapid communications. 1997;18(8):659-65.
45. Hummelen JC. Electrospray Mass Spectrometry-Of Poly (propylene imine) Dendrimersfl The Issue of Dendritic Purity or Polydispersity. Chem Eur J. 1997;3(9).
46. Sakthivel T, Toth I, Florence AT. Synthesis and physicochemical properties of lipophilic polyamide dendrimers. Pharmaceutical research. 1998;15(5):776-82.
47. Larre C, Bressolles D, Turrin C, Donnadieu B, Caminade A-M, Majoral J-P. Chemistry within megamolecules: Regiospecific functionalization after construction of phosphorus dendrimers. Journal of the American Chemical Society. 1998;120(50):13070-82.
48. Chu B, Hsiao BS. Small-angle X-ray scattering of polymers. Chemical reviews. 2001;101(6):1727-62.
49. Prosa TJ, Bauer BJ, Amis EJ, Tomalia DA, Scherrenberg R. A SAXS study of the internal structure of dendritic polymer systems. Journal of Polymer Science Part B: Polymer Physics. 1997;35(17):2913-24.
50. Rietveld IB, Smit JA. Colligative and viscosity properties of poly (propylene imine) dendrimers in methanol. Macromolecules. 1999;32(14):4608-14.
51. Topp A, Bauer BJ, Klimash JW, Spindler R, Tomalia DA, Amis EJ. Probing the location of the terminal groups of dendrimers in dilute solution. Macromolecules. 1999;32(21):7226-31.
52. Hofkens J, Verheijen W, Shukla R, Dehaen W, De Schryver F. Detection of a single dendrimer macromolecule with a fluorescent dihydropyrrolopyrroledione (DPP) core embedded in a thin polystyrene polymer film. Macromolecules. 1998;31(14):4493-7.
53. Gensch T, Hofkens J, Heirmann A, Tsuda K, Verheijen W, Vosch T, et al. Fluorescence detection from single dendrimers with multiple chromophores. Angewandte Chemie International Edition. 1999;38(24):3752-6.
54. Zeng F, Zimmerman SC, Kolotuchin SV, Reichert DE, Ma Y. Supramolecular polymer chemistry: design, synthesis, characterization, and kinetics, thermodynamics, and fidelity of formation of self-assembled dendrimers. Tetrahedron. 2002;58(4):825-43.
55. Francese G, Dunand FA, Loosli C, Merbach AE, Decurtins S. Functionalization of PAMAM dendrimers with nitronyl nitroxide radicals as models for the outer‐sphere relaxation in dentritic potential MRI contrast agents. Magnetic resonance in chemistry. 2003;41(2):81-3.
56. Tabakovic I, Miller LL, Duan RG, Tully DC, Tomalia DA. Dendrimers peripherally modified with anion radicals that form π-dimers and π-stacks. Chemistry of materials. 1997;9(3):736-45.
57. Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JR. Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proceedings of the National Academy of Sciences. 1996;93(10):4897-902.
58. Mourey TH, Turner S, Rubinstein M, Fréchet J, Hawker C, Wooley K. Unique behavior of dendritic macromolecules: intrinsic viscosity of polyether dendrimers. Macromolecules. 1992;25(9):2401-6.
59. Matos M, Hofkens J, Verheijen W, De Schryver F, Hecht S, Pollak K, et al. Effect of core structure on photophysical and hydrodynamic properties of porphyrin dendrimers. Macromolecules. 2000;33(8):2967-73.
60. Dantras E, Dandurand J, Lacabanne C, Caminade A-M, Majoral J-P. Enthalpy relaxation in phosphorus-containing dendrimers. Macromolecules. 2002;35(6):2090-4.
61. Trahasch B, Stühn B, Frey H, Lorenz K. Dielectric relaxation in carbosilane dendrimers with perfluorinated end groups. Macromolecules. 1999;32(6):1962-6.
62. Pavlov G, Errington N, Harding S, Korneeva E, Roy R. Dilute solution properties of lactosylated polyamidoamine dendrimers and their structural characteristics. Polymer. 2001;42(8):3671-8.
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Published
2021-04-15
How to Cite
Kumar, I., Dhiman, S., Palia, P., Kumar, P., & Sharma, N. (2021). Dendrimers: Potential Drug Carrier For Novel Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 9(2), 70–79. https://doi.org/10.22270/ajprd.v9i2.945
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Section
Review Articles
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