Chrysophyllum Albidum and Its Potential Damage to the Kidney of Wistar Rats

Authors

  • Nweke E lizabeth O Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria
  • Opara Julia K Department of Anatomy, Faculty of Basic Medical Sciences, Gregory University Uturu, Abia State,Nigeria
  • Obiesie Ifechukwu J Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Anambra State,  Nigeria

DOI:

https://doi.org/10.22270/ajprd.v9i1.917

Keywords:

Body weight; Chrysophyllumalbidum; Creatinine; kidney; Urea; Wistar rats; Histology

Abstract

Objective: The study was aimed at determining the effect of graded doses of Chrysophyllumalbidum on the kidney.

Materials and Methods:  Twenty wistar rats (190-220 grams) were used in this study and they were randomly allocated into four groups of five rats each. Group A received food and distilled water only while groups B, C and D were treated with 100 mg/kg, 200 mg/kg 300 mg/kg of Chrysophyllumalbidum leaf extract respectively. The study lasted for three weeks after which the animals where sacrificed and their blood samples and kidney collected for examination.

Results: The result from this study showed a significant decrease (p<0.05) in body weight in group of all treated groups. Also, there was a significant increase (p<0.05) in kidney weight in group C but a non-significant increase (p>0.05) in group B and D when compared to group A. In addition, the serum urea and creatinine level showed a significant decrease (p<0.05) in the treated groups when compared with that of group A. Histopathological findings revealed a mild to moderate changes in the cytoarchitecture of the kidney.

Conclusion: This result of this study suggests that ethanolic leaf extract of Chrysophyllumalbidum may have the tendency of being toxic to the kidney tissue when consumed at higher doses.

 

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Author Biographies

Nweke E lizabeth O, Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria

Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria

Opara Julia K, Department of Anatomy, Faculty of Basic Medical Sciences, Gregory University Uturu, Abia State,Nigeria

Department of Anatomy, Faculty of Basic Medical Sciences, Gregory University Uturu, Abia State,Nigeria

Obiesie Ifechukwu J, Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Anambra State,  Nigeria

Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Anambra State,  Nigeria

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Published

2021-02-15

How to Cite

lizabeth O, N. E., K, O. J., & Ifechukwu J, O. (2021). Chrysophyllum Albidum and Its Potential Damage to the Kidney of Wistar Rats. Asian Journal of Pharmaceutical Research and Development, 9(1), 27–32. https://doi.org/10.22270/ajprd.v9i1.917

Issue

Vol. 9 No. 1 (2021): Vol 9 No 1 (2021): Vol 9 No 1 (2021): Volume 9 Issue 1 Jan - Feb. 20201

Section

Research Articles

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