Evaluation of Potential Drug Side Effects in Multidrug-Resistant Tuberculosis Patients who have been Diagnosed by Genexpert Method

  • Fenny Hasanah Faculty of Pharmacy Universitas Tjut Nyak Dhien Medan, Indonesia
  • Eva Sartika Dasopang Faculty of Pharmacy Universitas Tjut Nyak Dhien Medan, Indonesia
  • Tedy Kurniawan Bakri FMIPA Universitas Syiah Kuala Darussalam Banda Aceh, Indonesia
  • Darmayanto D Faculty of Pharmacy Universitas Sumatera Utara Indonesia

Abstract

Objective: to evaluation potential drug side effects in multidrug-resistant tuberculosis patients who have been diagnosed by genexpert method


Design: this research used a descriptive analysis research design. The population used in this study were MDR-TB patients at the DOTS TB and MDR TB Poly in RSUP Haji Adam Malik Medan in 2017-2019, the research sample obtained was 100 patients and data collection used a cross sectional approach.


Interventions: the intervened variable were therapeutic regimen, used of additional drugs and duration of therapy


Main outcome measures: the main measurement in this study was therapeutic side effects


Results: the results showed that treatment of MDR-TB patients mostly used the standard combination regimen, namely Km-Lfx-Eto-Cs-Z- (H) - (E) as much as 35%. Side effect found was nausea at 20.55%. The use of additional vitamin B6 drugs in MDR-TB patients was 92% because treatment using kanamycin, etionamide, levofloxacin and cycloserine had side effects of peripheral neuropathy. Of the length of treatment that was still undergoing treatment in 2019, the highest number was 59%.


Conclusion: it could  be concluded the most common side effect found in the average number was nausea at 20.55% and peripheral neuropathy.


 

Keywords: Side effect, Multidrug-Resistant, Tuberculosis, Genexpert

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Author Biographies

Fenny Hasanah, Faculty of Pharmacy Universitas Tjut Nyak Dhien Medan, Indonesia

Faculty of Pharmacy Universitas Tjut  Nyak Dhien Medan, Indonesia

Eva Sartika Dasopang, Faculty of Pharmacy Universitas Tjut Nyak Dhien Medan, Indonesia

Faculty of Pharmacy Universitas Tjut  Nyak Dhien Medan, Indonesia

Tedy Kurniawan Bakri, FMIPA Universitas Syiah Kuala Darussalam Banda Aceh, Indonesia

FMIPA Universitas Syiah Kuala Darussalam Banda Aceh, Indonesia

Darmayanto D, Faculty of Pharmacy Universitas Sumatera Utara Indonesia

Faculty of Pharmacy Universitas Sumatera Utara Indonesia

References

1. Paramitha. Perbandingan Positivitas Metode MODS, Pewarnaan Zn dan Metode Genexpert untuk mendeteksi M. Tuberculosis pada Pasien Meningitis TB. Majalah Kedokteran Bandung. 2018; 50.
2. Nawas, A. Penatalaksanaan TB –MDR Dan Strategi DOTS Plus. Jurnal Tuberkulosis Indonesia. 2010; 7:231
3. Nofryanda, Dr. Analisi molekuler pada proses resistensi mikobakterium tuberculosis terhadap obat – obat anti tuberculosis. Skripsi, Pulmonologi dan Ilmu Kedokteran Respirasi Fakultas Keedokteran Universitas Andalas Padang. 2010; 21-32.
4. Dasopang, E.S., Hasanah, F., & Nisak, C. Analisis Deskriptif Efek Samping Penggunaan Obat Anti Tuberculosis pada Pasien TBC di RSUD. Pirngadi Medan, Jurnal Penelitian Farmasi Herbal. 2019; 2:47.
5. Sugiyono. Metodologi Penelitian Kuantitatif Kualitatif. Bandung : Alfabeta. 2011. p. 31.
6. Notoatmodjo., 2012. Metode Penelitian Kesehatan. Jakarta: Rineka Cipta. 2012. p. 42.
7. Kemenkes RI. Tuberkulosis Temukan Obati Sampai Sembuh. Jakarta: Pusat Data dan Informasi Kementerian Kesehatan RI. 2018. p. 5.
8. Kemenkes RI. Petunjuk Teknis Manajemen Terpadu Pengendalian Tuberkulosis Resisten Obat. Jakarta : Kementerian Kesehatan RI. 2018. p.34
9. Dani, Rosdiana. Tuberkulosis Paru Resisten Obat dengan Komorbiditas Diabetes Mellitus. Jurnal Kesehatan Melayu 2017. 2017; 45-51.
10. Dasopang, E.S., Harahap, U., & Lindarto, D., 2015. Polifarmasi dan Interaksi Obat Pasien Usia Lanjut Rawat Jalan dengan Penyakit Metabolik, Jurnal Farmasi Klinis Indonesia. 2015; 4:236-237.
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How to Cite
Hasanah, F., Dasopang, E., Bakri, T., & D, D. (2021). Evaluation of Potential Drug Side Effects in Multidrug-Resistant Tuberculosis Patients who have been Diagnosed by Genexpert Method. Asian Journal of Pharmaceutical Research and Development, 9(1), 8-11. https://doi.org/https://doi.org/10.22270/ajprd.v9i1.903