Formulation, Optimised and Evaluation of Mouth dissolving film of Amoxapine
DOI:
https://doi.org/10.22270/ajprd.v9i1.885Keywords:
Depression, Patient Compliance, BCS II, Polomer188, Solvent CastingAbstract
Amoxapine is orally active, acts by decreasing the reuptake of norepinephrine and serotonin and used for depression. The research work was undertaken to formulate, optimize and evaluation of mouth dissolving film of amoxapine, so that rapid release of drug constituents and give faster action. Mouth dissolving film (MDF) is a better alternative compared to oral disintegrating tablet due to patient compliance. Amoxapinebelongs to Biopharmaceutics Classification System ClassII, means drug have low solubility. The problem is resolved by using Polomer188. MDF prepared by solvent casting method. For preparation of film, hydrophilic polymers were selected as film forming polymers. Different polymers were selected such as different grades of Hydroxyl Propyl Methyl Cellulosei.e. E5, E15, E50.Selection of plasticizer was also done and PEG-400 was found best giving better results. It was found that formulation contain desiredphysio-mechanical properties.
Keywords- Depression, Patient Compliance, BCS II, Polomer188, Solvent Casting
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2. Ayenew Z, Puri V, Kumar L,BansalAK. Trends in pharmaceutical taste masking technologies: a patent review. Recent Patents on Drug Delivery and Formulation. 2009; 3(1):26–39.
3. Anand V,Kataria M ,KukkarV, SaharanV, Choudhury PK. The latest trends in the taste assessment of pharmaceuticals. Drug Discovery Today. 2007; 12(5-6):257–265.
4. Tiwari G, TiwariR, RaiKA. Cyclodextrins in delivery systems: applications. Journal of Pharmacy &Bioallied Sciences. 2010; 2(2):72–79.
5. Sharma A, Jain CP, Tanwar YS. Preparation and Characterization of Solid dispersion of Carvedilol with Polomer 188.2013; 58(1):1553-1557.
6. de Zwart PL, Jeronimus BF, de Jonge P. Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review. Epidemiology and Psychiatric Sciences. 2019; 28(5):44–562.
7. Khushboo, Sharma B.Antidepressants: mechanism of action, toxicity and possible amelioration. Journal of Applied Biotechnology & Bioengineering. 2017;3(5):437‒448.
8. Tripathi KD. Drugs used in Mental Illness: Antidepressants and Antianxiety. Essential of Medical Pharmacology. Seventh Edition. Jaypee Brothers Medical Publishers LTD;2013. p.454.
9. Patil P, Shrivastava SK. Fast Dissolving Oral Films: An Innovative DrugDeliverySystem. International Journal of Science and Research. 2014; 3(7):2088-2093.
10. Priyanka, Kumar K, Teotia D. A Comprehensive Review on Pharmaceutical Oral Dissolving Films. Journal of Drug Delivery and Therapeutics.2019; 9(5-S):170-174.
11. Gholve S, Savalsure S,Bhusnure O,Suryavanshi S, Birajdar M. Formulation and Evaluation of Oral Fast Dissolving Sublingual Film of Propranolol HCl. International Journal of Pharma Research and Health Sciences. 2018; 6(2):65-72.
12. Sri KV,Rohini P,Reddy GK. Montelukast sodium oral thin film: Formulation and In Vitro evaluation. Asian Journal of Pharmaceutical and Clinical Research. Revised 2012; 5(4):266-270.
13. Doshi A,KoliyoteS, Joshi B.Design and Evaluation of Buccal Film of Diclofenac Sodium. International Journal of Pharmacy and Biological Sciences. 2011; 1(1):17-30.
14. Dahiya M,Saha S, Shahiwal AF. A Review on Mouth Dissolving Films:Current Drug Delivery. Bentham Science Publishers Ltd. 2009; 6(5):469-476.
15. BashaN. Solubility enhancement of Clozapine using Superdisintegrants by solid dispersion method. 2015;1(1):32-88.
16. Rangari S,Patil S, Mahajan R, Ahmed A, Raut NA. Development of ultraviolet spectrophotometric method for analysis of amoxapine in pharmaceutical dosage form. Asian Journal of Pharmaceutical and Clinical Research. 2018; 11(3): 269-271
17. Joshi M. Salts of Amoxapine with Improved Solubility for Enhanced Pharmaceutical Applicability. ACS Omega. 2018; 3(2):2406−2416
18. Kamalakkannan V, Puratchikody A, Masilamani K, Senthilnathan B. Solubility enhancement of poorly soluble drugs by solid dispersion technique– A review. Journal of Pharmacy Research. 2010;3(9):2314-2321.
19. Surendran AS, Iyer SR. Fast dissolving tablet using solid dispersion technique: An overview. Indo American Journal of Pharmaceutical Research. 2015;5(2):668-679.
20. Siddiqui MN, Garg G, Sharma PK. Short review on A novel approach in oral fast dissolving drug delivery system and their patent. Advance in Biological Research. 2011; 5(6):291-303.
21. Anand V, Kataria M, Kukkar V, Saharan V, Choudhury PK. The latest trends in the taste assessment of pharmaceuticals. Drug Discovery Today. 2007; 12(5-6):257-265.
22. Buchi N, Nalluri B, Sravani V, Saisri A, Sribramhini R, Maheswari K M. Development and evaluation f mouth dissolving films of sumatriptan succinate for better therapeutic efficacy. J App Pharm Sci. 2013; 3(8):161-166.
23. Nair AB, Kumria R, Harsha S, Attimarad M, Al-Dhubiab BE, Alhaider IA. In-vitro techniques to evaluate buccal films. J Control Release. 2013; 166(1):10-21.
24. Ali MS, Vijendar C, Kumar SD, Krishnaveni J. Formulation and evaluation of fast dissolving oral films of diazepam. J Pharm. 2016;4(3):1-5.
25. Bhyan B, Jangra S, Kaur M, Singh H.Orally fast dissolving films: Innovations in formulation and technology. Int J Pharm Sci. Rev Res 2011; 9(2):50-57.
26. Kumar GV, Krishna RV, William GJ, Konde A. Formulation and evaluation of buccal films of salbutamol sulphate. Indian J Pharm Sci. 2005;67(2):160-164.
27. Venkata A, Shireesh MR, Kiran P. A review on oral thin fast dissolving films; recent trends of dosage form for quick release. Int J Pharm Bio Sci. 2014; 5(4):54-67.
28. Pandit JK, Balamurugan K, Choudary PK, Balasubtamaniam J. Systemic absorption of propranolol hydrochloride from bucco adhesive films. Indian J Pharm Sci. 2001; 63(6):473-480.
29. Raykar Meghana, Malarkodi Velraj. An Overview on Mouth Dissolving Film. Asian Journal of Pharmaceutical and Clinical Research. 2018; 11(4):44-47.
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