Anti Inflammatory Potential of Euphoria Hirta L. Leaves In Jaipur Region

  • Gunjan Verma Arya College of pharmacy, kukas, Jaipur, Rajasthan
  • Vandana Sharma Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India
  • Ramesh Pareek Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Abstract

Introduction: Euphorbia hirta Linn. (E.hirta L.) is a medicinal herb belonging to the family Euphorbiaceae. It is commomly known as Asthma plant, Duddhi, Bara duddhi. It has been claimed for the various medicinal properties such as inflammation, diarrhoea, bronchitis, kidney stones, peptic ulcer, menstrual problems etc.


Objective: the goal of our research work is to assessing the anti inflammatory activity of E.hirta L. leaves in regards to phytochemical studies.


Methods: The method carragennan induced paw edema in rats was used to assess the anti inflammatory activity of aqueous extract of E.hirta L. leaves. The extract was obtained by maceration method and the analysis of phytochemicals was carried out by performing different chemical test in laboratory. Crude aqueous extract was given orally at different doses of 100mg/kg, 300mg/kg and 500mg/kg in wistar albino rats 30mins before carragennan injection. Ibuprofen (50mg/kg) was taken as reference drug. The volume of paw edema was measured by using plethysmometer at 1, 2 and 3 hr after carragennan administration.


Results: The preliminary phytochemical study reveals the availibility of flavonoids, terpenoids, sterols, glycosides, tannins etc in different solvents of crude drug extract. The anti inflammatory effect of crude drug extract was exhibited a remarkable dose dependent reduction in paw edema volume. The inhibitory effect was highest at 500mg/kg dose of drug. Extract and ibuprofen showed 52% and 66% inhibition of paw edema respectively, at 3hr after carragennan administration.


Conclusion: E.hirta L. leaves aqueous extract has a strong anti inflammatory activity. These consequences help in the traditional uses of the plants and in the development of new treatments.


 

Keywords: Aqueous extract, flavonoids, Anti inflammatory activity.

Downloads

Download data is not yet available.

Author Biographies

Gunjan Verma, Arya College of pharmacy, kukas, Jaipur, Rajasthan

Arya College of pharmacy, kukas, Jaipur, Rajasthan

Vandana Sharma, Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Ramesh Pareek, Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

References

1. Rao AL, Dathi S. Current trends in herbal medicines. Journal of pharmacy. Research,2010; 3(1):109-113.
2. Sahoo N, Manchikanti P, Dey S. Herbal drugs: standards and Regulation, Ftoterapia; 2010;DOI:10.1016/j.Fitote.2010.02.001.
3. Shah K, Sheth D, Tirgar P, Desai T, Kher M, Rangani D, Shah KV. Anti-Inflammatory Activity of Triticum Aestivum on Carrageenan Induced Paw Edema In Wistar Rats, Pharmacologyonline 2,2010:745-751.

4. C. Kumar D. Pharmacognosy can help minimize accidental misuse of herbal medicine, Current Science; 2007(93), Nov.25.
5. Shinde VM, Dhawal K, Potdar M, Mahadik KR. Application of quality control principles to Herbal Drugs. Internatinal Journal of Phytomedicine 1,2009:4-8
6. Agarwal SS, Tamrakar BP, Paridhavi M. Expectorants/Drug reduces cough. In: Clinically useful herbal drugs. Ahuja publisher; New Delhi : 233-235.
7. Kumar S, Kumar D. evaluation of antidiabetic activity of euphorbia hirta linn. in streptozotocin induced diabetic mice, Indian journal of natural products and resources, 2010; 1(2):200-203.
8. Khan S, Rehman A, Riaz N and Malik A. Isolation studies on Cotoneaster racemiflora. J Chem Soc Pakistan 2007; 29(6):620-623.
9. Rahman MS, Rana S, Islam AA. Antithrombotic and anti-inflammatory activities of leaf methanolic extract of Euphorbia hirta Lin. Int J Complement Alt Med. 2019;12(4):154-62.
10. Ekpo OE, Pretorius E. Asthma, Euphorbia hirta and its anti-inflammatory properties. South African Journal of Science. 2007;103(5-6):201-3.
11. Adedapo AA, Abatan MO, Idowu SO and Olorunsogo OO. Effects of chromatographic fractions of Euphorbia hirta on the rat serum biochemistry. African Journal of Biomedical Research 2005; 8:185- 189.
12. Ubaid mohd., Sharma S, Chaudhary.S. D, saxena N. Review article on Euphorbia hirta, World journal of pharmaceutical research, 2018; 7(18):585-597.
13. Arsule CS , Sable KV, Preliminary Phytochemical Analysis of Euphorbia hirta Linn. Leaves, Int. J. of Life Sciences, 2017; 5(4):746-748.
14. Junaid R Shaikh, MK Patil, Qualitative tests for preliminary phytochemical screening: An overview, International Journal of Chemical Studies 2020; 8(2):603-608.
15. Mudiganti Ram Krishna Rao , S. Selva Kumar, preliminary phytochemical analysis of herbal plant hygrophila auriculata, indo american journal of pharmaceutical sciences, 2017; 4(12):4580-4583.
16. Thilagavathi.T, Arvindganth.R, Vidhya.D, Dhivya .R, preliminary phytochemical screening of different solvent mediated medicinal plant extracts evaluated, Int. Res. J. Pharm. 2015;6(4):246-248.
17. Lerato N. M , Samkeliso T, Michael P, Preliminary Phytochemical Screening of Crude Extracts from the Leaves, Stems, and Roots of Tulbaghia violacea, International Journal of Pharmacognosy and Phytochemical Research 2017; 9(10):1300-1308.
18. Amri O, Zekhnini A, Bouhaimi A, Tahrouch S, Hatimi A. Anti-inflammatory activity of methanolic extract from Pistacia atlantica desf. leaves. Pharmacognosy Journal. 2018; 10(1):71-76.
19. Ammar NM, Al-Okbi SY, Mohamed DA. Study of the anti-inflammatory activity of some medicinal edible plants growing in Egypt. Journal of Islamic Academy of Sciences. 1997; 10(4):113-22.
20. Upadhyay A, Chattopadhyay P, Goyary D, Mazumder PM, Veer V. Anti-inflammatory effect of euphorbia hirta leaf extract in rats and modulation of inflammation-associated prostaglandins (PGE-2) and Nitric Oxide (NO) expression in RAW264. 7 macrophage. Journal of Pharmaceutical Sciences and Pharmacology. 2014 Mar 1; 1(1):68-73.
Statistics
95 Views | 107 Downloads
How to Cite
Verma, G., Sharma, V., & Pareek, R. (2021). Anti Inflammatory Potential of Euphoria Hirta L. Leaves In Jaipur Region. Asian Journal of Pharmaceutical Research and Development, 9(1), 54-59. https://doi.org/https://doi.org/10.22270/ajprd.v9i1.884