Formulation of Black Cumin (Nigella Sativa L.) Ethanol Extract Gel Preparation with Addition of Dimeticone as Hair Tonic

  • Wulansari S Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Reveny J Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Nainggolan M Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Abstract

Objective: This study aims to formulate a gel preparation for the ethanol extract of Black Cumin (Nigella sativa L.) with the addition of dimethicone as a hair tonic.


Methods: Characterization examinations of Black Cumin (Nigella sativa L.) simplicia were carried out. Simplicia is macerated using 80% ethanol and concentrated in a rotary evaporator then in a freeze dryer until the extract is thick. The concentrations taken are 3%, 5% and 7%. Then tested the simplicia characterization, rat hair growth activity and an evaluation of the preparations was carried out, namely the homogeneity, organoleptic test, and microbial contamination test.


Results: The results of the simplicia characterization test were water content of 6.63%, water soluble content of 24.64%, total ash content of 3.55% and acid insoluble ash content of 0.29%. Hair tonic preparations are stable in storage for up to 12 weeks from organoleptic, homogeneity. The hair growth activity of the ethanol extract hair tonic gel from 3 concentrations, the best was 7% (1.96 ± 0.00).


Conclusion: Black Cumin (Nigella sativa L.) ethanol extract gel has hair growth activity.


 

Keywords: Black cumin (Nigella sativa L.), hair tonic, hair growth activity

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Author Biographies

Wulansari S, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Reveny J, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Nainggolan M, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

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How to Cite
S, W., J, R., & M, N. (2020). Formulation of Black Cumin (Nigella Sativa L.) Ethanol Extract Gel Preparation with Addition of Dimeticone as Hair Tonic. Asian Journal of Pharmaceutical Research and Development, 8(6), 42-45. https://doi.org/https://doi.org/10.22270/ajprd.v8i6.875