The Effect of Infusion Breadfruit Leaves (Artocarpus Altilis (Parkinson) Fosberg) On Blood Glucose Levels in Male Mice (Mus Musculus) Diabetes Mellitus Type 2
Objective: The purpose of this study was to determine the content of secondary metabolite compounds contained in breadfruit leaf infusions which affect blood glucose levels and to determine the effective concentration of breadfruit leaf infusions which play a role in lowering blood glucose levels. Methods: The research method was carried out experimentally with the stages of making simplicia, making infusion, phytochemical screening and testing the breadfruit leaf infusion using the alloxan induction method. Antidiabetic testing was carried out in vivo on animal testing with 5 treatment groups (Na-CMC 1% w / v, Glibenclamide 0.65 mg / kg BW, breadfruit leaf infusion 300 mg / kg BW, 400 mg / kg BW, 500 mg / kg BW). Results: The results of phytochemical screening on breadfruit leaf infusion showed flavonoids, saponins and tannins. The results of the antidiabetic test with the alloxan induction method showed a decrease in blood glucose levels at the concentration of breadfruit leaf infusion 300 mg / kg BW, 400 mg / kg BW, 500 mg / kg BW. Conclusion: Breadfruit leaf infusion has an effect on reducing blood glucose levels in male type 2 diabetes mellitus mice.
2. Sairam S, & Asna U. Artocarpus altilis-Mode of Anti-Hyperglycemic Activity: Elucidation By Suitable In-Vitro and Ex-Vivo Techniques. International Journal Pharmaceutical Sciences and Research, 2013; 4(8):3013–3019.
3. Palleria C, Christian L, Francesca M, Elena S, Giovambattista D.S, Franco A, & Emilio R. Potential Effects of Current Drug Therapies on Cognitive Impairment in Patient With Type 2 Diabetes. Frontiers in Neuroendocrinology, 2016:1–17.
4. Kumaraswamy S, & Senthamarai SV. Assessment of Nutritional Value and Potential Metal Toxicity in Fruit of Artocarpus altilis
(Parkinson) Fosberg (seedless) in India. International Research Journals (IJSREM), 2020; 11(1):1-18.
5. Simanjuntak H.A. Antibacterial Activity of Ethanolic Extract of Kitolod (Hippobroma longiflora) Leaf Against Staphylococcus aureus and Salmonella typhi. AJPRD, 2020; 8(1): 52-54.
6. Jagtap U.B, & Bapat VA. Artocarpus: A Review of Its Tradisional Uses, Phytochemistry and Pharmacology. J. Ethnopharmacol, 2010;129(2):142–166.
7. Chan E.W.C, Siu K.W, Joseph T, & Hung TC. Chemistry and Pharmacology of Artocarpin: An Isoprenyl Flavone from Artocarpus Species. Sys Rev Pharm, 2018;9(1):58–63.
8. Gurning K, Iksen, Helen A.S, & Hermawan P. Identification of The Chemical Compound of Essential Oil from Ketumbar (Coriandrum sativum L.) Leaves With GC-MS. Pharmacogn J, 2020; 12(5):1019-1023.
9. Kerem Z, German S, & Vardeen O. Microwave Assisted Extraction of Bioactive Saponins From Chickpea (Cicer arietinum L.). Journal of Science Food and Agriculture, 2005; 85:406-412.
10. Olalekan A.J, Komolafe E.A, & Imokhuede B. Nutritional and Phytochemical Compositions of Fireweed (Crassocephalum crepidioides). Inter.J.Agric.Technol, 2013; 4(2):371-381.
11. Okwu O.E, & Okwu M.E. Chemical Composition of Spondias mombin L. Plant Parts. J.Sustain.Agri.Environ, 2004; 6:140–147.
12. Asekun O.T, Asekunowo A.K, & Balogun K.A. Proximate Composition, Elemental Analysis, Phytochemistry and Antibacterial Properties of the Leaves of Costusafer KerGawl and Cedrela odorata L. From Nigeria. Journal of Sci.Res.Dev, 2013; 14:112- 118.
13. Hari A, Revikumar K.G, & Divya D. Artocarpus: A Review of Its Phytochemistry And Pharmacology. Journal of Pharma Search, 2014;9(1):7-12.
14. Leng LY, Nuramira B.N, Khor CY, Norawanis B.A.R, & Abdul R.S. Antioxidant and Total Phenolic Content of Breatfruit (Artocarpus altilis) Leaves. MATEC Web of Conference, 2018:150.
15. Ajayi O.B, & Godwin O.A. Inhibitory Effect of Artocarpus altilis leaf powder supplemented diet on key enzymes relevant to acute type-2 diabetes in alloxan induced diabetic rats. Pharmacoloonline, 2019:195-202.
16. Sari D.R.A.P, Fitriani F.A, Yulia Y.D, & Risfah Y. Breadfruit leaves extract (Artocarpus altilis) effect on Pancreatic Damage in Diabetic type II animal model induced by alloxan-nicotinamide. Medicina Clinica Pratica, 2020; 3(S1):1-4.
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