Determination of Sun Protection Factor of Blemish Balm Nanocream Containing Avobenzone, Octyl Methoxycinnamate, and Vitamin C

  • Julianty S. M Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Arianto A Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Yuandani Y Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Abstract

Objective: The aim of this study was to determine sun protection factor of blemish balm nanocream (BB nanocream) containing avobenzone, octyl methoxycinnamate and vitamin C.


Method: The formulation of blemish balm nanocreams using a combination of a variety of concentrations of vitamin C (5, 7.5, and 9%), 3% avobenzone, and 7.5% octyl methoxycinnamate. The safety of the BB nanocream containing the highest concentration of vitamin C was examined using skin and eye irritation tests on the rabbit. SPF value of BB nanocreams determined by using UV-Vis Spectrophotometry method and compared with BB cream.


Results: All BB nanocream containing vitamin C, avobenzone, and octyl methoxycinnamate did not irritate the eyes and skin of rabbits. The SPF value of BB nanocream containing a combination of 3% avobenzone, 7.5% octyl methoxycinnamate and vitamin C of 5, 7 and 9% were 18.0497, 21,0857, and 21.5883 respectively. The SPF value of BB nanocream without avobenzone, octyl methoxycinnamate and vitamin C was 10.4798 and bb krim was 15,8515.


Conclusions: All BB nanocream formula containing 3% avobenzone, 7.5% octyl methoxycinnamate and Vitamin C (5%, 7%, and 9%) were not irritating the eyes and rabbit skin. The BB nanocream containing 3% avobenzone, 7.5% octyl methoxycinnamate and 9% vitamin C has the highest SPF value.


 

Keywords: BB Cream, Nanocream, Vitamin C, Avobenzone and Octyl methoxycinnamate

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Author Biographies

Julianty S. M, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

DepartVment of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Arianto A, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Yuandani Y, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

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How to Cite
M, J., A, A., & Y, Y. (2020). Determination of Sun Protection Factor of Blemish Balm Nanocream Containing Avobenzone, Octyl Methoxycinnamate, and Vitamin C. Asian Journal of Pharmaceutical Research and Development, 8(5), 9-13. https://doi.org/https://doi.org/10.22270/ajprd.v8i5.841