Effect of Gel Formulation of Corn Silk Extract (Stigma Maydis) On Burn Wound Healing In Male White Rat

  • Nessa Nessa Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586
  • Noni Rahayu Putri Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586
  • Eka Fitrianda Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586
  • Elmitra Elmitra Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586
  • Ridho Asra School of Pharmaceutical Science (STIFARM) Padang, Indonesia

Abstract

Objectives: Burns are damage or loss of tissue caused by exposure to very high temperatures. This study was to determine the effect of gel formulation from corn silk (Stigma maydis) in healing burns in male white rats.


Data Sources Study Selection: This research is an experimental research of the effect of gel formulation from corn silk (Stigma maydis) in healing burns in male white rats


Summary of contents of the article: Five groups are used in this study. Group I (induced hot metal), group II (induced hot metal + gel base), group III (induced hot metal + 10% corn silk extract gel), group IV (induced hot metal + 15% gel of corn silk extract gel), group V (induced hot metal + B® gel). Observations were made for 21 days. The results of this study are the average % of burns healing on day 7, 14 and 21 : group I (27.29%, 63.03%, 100%), group II (35.39%, 60.16 %, 100%), group III (37.16%, 65.34%, 100%), group IV (36.89%, 68.23%, 100%), group V (32.81%, 66, 48%, 100%). The period of epithelialization of skin tissue are groups I, II, III on day 16, group IV on day 14 and group V on day 17. The mean results of the epithelialization scores for groups I, II, III, IV and V (2, 2, 3, 3, 3), the mean fibroblast score results (2,7, 2,9, 3, 3, 3), groups I, II, III, IV and V collagen fiber density groups I, II, III , IV and V (2,2, 2,8, 3,6, 3,9, 3,9). The two-way ANOVA statistical analysis test on % burn healing was not significant (p> 0.05), and the one-way ANOVA statistical analysis test at the period of epithelialization was not significant (p>0.05) and the histology of epithelialization and fibroblasts was not significant (p>0.05), the density of collagen fibers was significant (p<0.05).


Conclusion: The conclusion of this study is corn silk extract gel (Stigma maydis) 10% and 15% have the effect on the healing process of burns and can be formulated in gel dosage forms.

Keywords: Burn; Corn Silk Extract (Stigma maydis); Epithelialization Period; Histopathology.

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Author Biographies

Nessa Nessa, Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Noni Rahayu Putri, Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Eka Fitrianda, Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Elmitra Elmitra, Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Faculty of Pharmacy, University of Perintis, West Sumatera, Indonesia 25586

Ridho Asra, School of Pharmaceutical Science (STIFARM) Padang, Indonesia

School of Pharmaceutical Science (STIFARM) Padang, Indonesia

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How to Cite
Nessa, N., Putri, N., Fitrianda, E., Elmitra, E., & Asra, R. (2020). Effect of Gel Formulation of Corn Silk Extract (Stigma Maydis) On Burn Wound Healing In Male White Rat. Asian Journal of Pharmaceutical Research and Development, 8(6), 20-27. https://doi.org/https://doi.org/10.22270/ajprd.v8i6.821