Effect of Gel Formulation of Corn Silk Extract (Stigma Maydis) On Burn Wound Healing In Male White Rat
DOI:
https://doi.org/10.22270/ajprd.v8i6.821Keywords:
Burn; Corn Silk Extract (Stigma maydis); Epithelialization Period; Histopathology.Abstract
Objectives: Burns are damage or loss of tissue caused by exposure to very high temperatures. This study was to determine the effect of gel formulation from corn silk (Stigma maydis) in healing burns in male white rats.
Data Sources Study Selection: This research is an experimental research of the effect of gel formulation from corn silk (Stigma maydis) in healing burns in male white rats
Summary of contents of the article: Five groups are used in this study. Group I (induced hot metal), group II (induced hot metal + gel base), group III (induced hot metal + 10% corn silk extract gel), group IV (induced hot metal + 15% gel of corn silk extract gel), group V (induced hot metal + B® gel). Observations were made for 21 days. The results of this study are the average % of burns healing on day 7, 14 and 21 : group I (27.29%, 63.03%, 100%), group II (35.39%, 60.16 %, 100%), group III (37.16%, 65.34%, 100%), group IV (36.89%, 68.23%, 100%), group V (32.81%, 66, 48%, 100%). The period of epithelialization of skin tissue are groups I, II, III on day 16, group IV on day 14 and group V on day 17. The mean results of the epithelialization scores for groups I, II, III, IV and V (2, 2, 3, 3, 3), the mean fibroblast score results (2,7, 2,9, 3, 3, 3), groups I, II, III, IV and V collagen fiber density groups I, II, III , IV and V (2,2, 2,8, 3,6, 3,9, 3,9). The two-way ANOVA statistical analysis test on % burn healing was not significant (p> 0.05), and the one-way ANOVA statistical analysis test at the period of epithelialization was not significant (p>0.05) and the histology of epithelialization and fibroblasts was not significant (p>0.05), the density of collagen fibers was significant (p<0.05).
Conclusion: The conclusion of this study is corn silk extract gel (Stigma maydis) 10% and 15% have the effect on the healing process of burns and can be formulated in gel dosage forms.
Downloads
References
2. Sheridan RL. Burns: A Practical Approach to Immediate Treatment and Long-Term Care. London: Manson Publishing. 2012.
3. WHO. 2014.Burns. [Online] “http://www.who.int/mediacentre/factsheet/fs365/en/#” [Accessed November 1, 2019.
4. Department of Health RI. Basic Health Research Jakarta: Body Research and Ministry of Health Development Health RI. 2013.
5. Ekrami A & Kalantar E. Bacterial Infections in Burn Patients at A Burn Hospital in Iran. IJMS, 2007; 126: 541-544.
6. Izzati Z. The Effectiveness of Wound Healing Roasted Senggani Leaf Ethanol Extract Ointment (Melastoma malabathricum L) in Male White Rats (Rattus norvegicus) Strain Wistar. Pontianak: Tanjungpura University. 2007.
7. Mansur A.P. The Effectiveness Test of Preparations Corn Silk Waste Cream (Zea Mays L.) Against Wound Healing of Diabetes Mellitus Mice. HSJ, 2017; 1(2):144-150.
8. Bhaigyabati T, Kirithika T, Ramya J, & Usha K. Phytochemical Constituents and Antioxidant Activity of Various Extracts of Corn Silk (Zea mays L). RJPBCS, 2011; 2(4):986–993.
9. Redha A. Flavonoids: Structure, Antioxidative Properties and Their Role in Biological Systems. Belian's Journal, 2010; 2 (9).
10. Ganiswarna S. Pharmacology and Therapy, 4th ed. Jakarta: Department of Pharmacology FKUI. 1995.
11. Wyatt Jonathan. Forensic Medicine. New York: Oxford University Press. 2011.
12. Langley CA, & Belcher D. Fasttrack: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press, London. 2008.
13. Harborne J. Guiding Phytochemical Methods for Modern Methods of Analyzing Plants. Bandung: ITB. 1987.
14. Department of Health RI. Indonesian Cosmetics Codex, Volume 1. Jakarta: Ministry of Health of the Republic of Indonesia. 1980.
15. Department of Health RI. Indonesian Pharmacopoeia, Edition IV. Jakarta: Director General of POM. 1995
16. Huynh-Ba K. Hand Book of Stability Testing in Pharmaceutical Development: Regulation, Methodologies, and Best Practice. New York: Spinger Science Business Media. 2008.
17. Lachman L, Lieberman HA, & Kaning JL. Theory and Practice of Industrial Pharmacy, 3rd edition. S. Suyatmi translation. Jakarta: University of Indonesia press. 1989.
18. Garg A, A Deepika, S Garg, & AK Sigla. Spreading of semisolid formulation. USA: Pharmaceutical Tecnology. 2002. Pp. 84-104.
19. Aponno JV, Paulina VYY, and Hamidah SS. The Effectiveness Test of the Ethanol Extract Gel of Guava Leaves (Psidium guajava Linn) To Wound Healing Infected with Staphylococcus aureus Bacteria in Rabbits (Orytolagus cuniculus). Pharmacon Pharmaceutical Scientific Journal. 2014.
20. Prasiddha J, Rosalina A, Teti E, Jaya M. Potential of corn silk (Zea mays L.) bioactive compounds for natural sunscreens: literature review. Journal of food and agro industry, 2016; 4(1): 40-5.
21. Ardiana T, Kusuma A, Firdausy M. The Effectiveness of Giving Binahong Gel (Anredera cordifolia) 5% Against Number of Fibroblast Cells in Post-Extraction Sockets Tooth Guinea pig (Caviatry). Dental journal, 2015; 2(1):64-70.
22. Paju N. Effectiveness Test of Extract Ointment Binahong Leaves (Anredera cordifolia Steenis in Rabbits (Oryctolagus cuniculus) Infected with Staphylococcus aureus bacteria. UNSRAT Pharmaceutical Scientific Journal, 2013; 2(1):53.
23. Nuria C, Faizatun A, Sumantri. Against Staphylococcus aureus ATCC 25923, Escherichia coliATCC5922, and Salmonella typhi ATCC1408. Mediagro Journal, 2002; 26(2)26-37
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).