The Application of Marine Natural Products (MNPS) In Anti-Covid-19 Therapeutics

  • Rajendra Singh Pawar SBS University Balawala, Dehradun-248161 (Uttarakhand) India
  • Mayank Dimri SBS University Balawala, Dehradun-248161 (Uttarakhand) India
  • Alok Maithani SBS University Balawala, Dehradun-248161 (Uttarakhand), India
  • Luv Kush SBS University Balawala, Dehradun-248161 (Uttarakhand), India

Abstract

The bioprospecting of MNPs for the treatment of COVID-19 virus was attempted. The marine biodiversity is a remarkable source of bioactive chemotherapeuticals. The structural uniqueness of selected MNPs was correlatedwith reported binding energies to ascertain structure activity relationship (SAR) features.


 

Keywords: Marine, COVID-19, Natural product Mpro, Structural uniqueness.

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Author Biographies

Rajendra Singh Pawar, SBS University Balawala, Dehradun-248161 (Uttarakhand) India

SBS University Balawala, Dehradun-248161 (Uttarakhand) India

Mayank Dimri, SBS University Balawala, Dehradun-248161 (Uttarakhand) India

SBS University Balawala, Dehradun-248161 (Uttarakhand) India

Alok Maithani, SBS University Balawala, Dehradun-248161 (Uttarakhand), India

SBS University Balawala, Dehradun-248161 (Uttarakhand), India

Luv Kush, SBS University Balawala, Dehradun-248161 (Uttarakhand), India

SBS University Balawala, Dehradun-248161 (Uttarakhand), India

References

1. Mognadamtousi, S. Z. M., Nikzad, S., Kadir, H. A, Abubakar, S., and Zandi, K. Potential antiviral agents from marine fungi: An overview. Marine Drugs, 2015; 13(7):4520-4538.https://doi.org/10.3390/md13074520
2. Mayer, A. M.; Rodriguez, A. D.; Berlinck, R. G.; Fusetani, N., Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune And nervous system, and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacon 2011; 153:191-222.
3. Park, J. Y. Kim, J. H.; Kwon, J. M.; Kwon, H. J.; Jeong, H. J.; Kim, Y. M.; Kim, D.; Lee, W. S.; Ryu, Y. B., Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava. Bioorg Med Chem 2013; 21:3730-3737.
4. Liu, L.; Heinrich, M.; Myers, S.’ Dworjanyn, S. A., Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review. J Ethnopharmacol 2012; 142:591-619.
5. Li, y.; Fu, X.; Duan, D.; Liu, X.; Xu, J.; Gao, X., Extraction and Identification of Phlorotannins from the Brown Alga, Sargassumfusiforme (Harvey) Setchell. Mar Drugs 2017; 15.
6. Nakao, Y.; Masuda, A.; Matsunaga, S.; Fusetani, N., Pseudotheonamides, serine protease inhibitors from the marine sponge Theonellaswinhoei. J. Am. Chem. Soc. 1999; 121:2425-2431.
7. Glombitza, K. W.; Keusgen, M., Fuhalols and Deshydroxyfuhalols from the Brown Alga Sargassum-Spinuligerum. Phytochemistry 1995; 38:987-995.
8. Yang. S. y., Pharmacophoremodeling and applications in drug discovery: challenges and recent advances. Drug Discov Today 2010; 15, 444-450.
9. Jin, Z.; Du, X.; Xu, Y.; Deng, Y.; Liu, M.; Zhao, Y.; Zhang, B.; Li, X.; Zhang, L,; Peng, C.; Duan, Y.; Yu, J.; Wang, L.; Yang, K.; Liu, F.; Jiang, R.; Yang, X.; You, T.; Liu, X.; Yang, X.; Bai, F.; Liu, H.; Liu, X.; Guddat, L. W.; Xu, W.; Xiao, G.; Qin, C.; Shi, Z.; Jiang, H.; Rao, Z.; Yang, H., Structure of Mpro from COVID-19 virus and discovery of its inhibitors. bioRxiv, 2020; 2002.2026.964882.
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How to Cite
Pawar, R., Dimri, M., Maithani, A., & Kush, L. (2020). The Application of Marine Natural Products (MNPS) In Anti-Covid-19 Therapeutics. Asian Journal of Pharmaceutical Research and Development, 8(6), 77-80. https://doi.org/https://doi.org/10.22270/ajprd.v8i6.809

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