Anti-COVID-19 natural products are spotlights for drug discovery and development

Authors

  • Rajendra Singh Pawar SBS University Balawala, Dehradun-248161 (Uttarakhand) India.
  • Mayank Dimri SBS University Balawala, Dehradun-248161 (Uttarakhand) India.
  • Alok Maithani SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

DOI:

https://doi.org/10.22270/ajprd.v8i4.785

Keywords:

Covid-19, Natural product, phytochemical and CLpro inhibitor.

Abstract

Traditional plants and marine natural products have plausible medicinal compounds of anti-COVID-19 potential. They became spotlights for the development and discovery of new marketable antivirals. The global COVID-19 pandemic invigorated medicinal chemists to evolve new feasible ideas for the non-toxic medications.

 

Downloads

Download data is not yet available.

Author Biographies

Rajendra Singh Pawar, SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

Mayank Dimri, SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

Alok Maithani, SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

SBS University Balawala, Dehradun-248161 (Uttarakhand) India.

References

1. An overview of basic molecular biology of SARS CoV-2 and current COVID-19 prevention straetgies June 7, 2020, doi 10, 20944 | preprints | 20.200600864.
2. D. C. Dinesh, S. lamilarasan, K. Rajaram, and E.Boura,̎ Antiviral Drug Targets of Single-Stranded RNA virus Causing Chronic Human Diseases,” Current drug targets, vol. 21, no.2. pp. 105-124, 2020.
3. H. Chen and Q. Du, ̎Potential natural compounds for preventing 2019-nCoV infection,” preprints. 2020
4. Ayush Sara.org – use of herbal medicines on Coronavirus vol.4 issue 4 April 2020 Acta scientific pharmaceutical Science.
5. A Reza zadeh et al- plants as prospective source of natural anti-COVID19 Compounds, April 15, 2020, doi:10.20944/preprints202004.0321.v1
6. Antonio Rescifina et.al. Inhibitors of SARS-CoV-2 Main protease from a Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study Research gate, doi:10.20944/preprints202003.0372.v1
7. Dong. S. Hu, and J. Gao,˝Discovering drugs to treat coronavirus disease 2019(COVID19),” Drug discoveries and therapeutics, vol. 14, no. 1, pp. 58-60,2020.
8. M. T. ulQamar, S. M. Alqahtani, M. A. Alamri, and L-L Chen, ̎Structural basis of SARS-CoV-2 3CLpro and anti- COVID-19 drug discovery from medicinal plants,” Journal of pharmaceutical Analysis, 2020/03/26/2020,
9. C.-N. Chen et al., ̎Inhibition of SARS-CoV 3C-like protease activity by theaflacin-3, 3’- digallate (TF3),” Evidence-Based Complementary and Alternative Medicine, vol. 2, no. 2, pp. 209-215, 2005.
10. K.Anand, H. Yang, M. Bartlam, Z. Rao, and R. Hilgenfeld, ̎Coronavirus main proteinase: target for antiviral drug therapy,” in Coronavirus with special emphasis on first insights concerning SARS: Springer, 2005, pp. 173-199.
11. N. Mohammadi and N. Shaghaghi, ̎ Inhibitory effect of eight secondary Metabolite from conventional Medicine plants on COVID 19 virus protease by Molecular Docking Analysis,” 2020.
12. C.-W. Lin et al., ̎Anti-SARS coronavirus 3C-like protease effects of Isatisindigotica root and plant-derived phenolic compounds,” Antiviral Research, vol. 68, no. l, pp. 36-42, 2005/10/01/2005,
13. C.-C. Wen et al., ̎Specific plant Terpenoids and Lignoids Possess Potent Antiviral Activities against severe Acute Respiratory Syndrome Coronavirus,” Journal of Medicinal Chemistry, vol. 50, no. 17, pp. 4087-4095, 2007/08/01 2007, doi: 10.1021/jm070295s.
14. J.-Y. Park et al., ̎Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV,” Journal of enzyme inhibition and medicinal chemistry, vol.31, no. l, pp. 23-30, 2016.
15. Y. B. Ryu et al., ̎SARS-CoV 3CLpro inhibitory effects of quinone-methidetriterpenes from Tripterygiumregelii,” Bioorganic and medicinal chemistry letters, vol. 20, no.6, pp. 1873-1876, 2010.
16. S. Jo, S. Kim, D. H. Shin, and M.-S. Kim, ̎Inhibition of SARS-CoV 3VL, protease by flavonoids,” Journal of Enzyme Inhibition and and Medicinal Chemistry, vol.35, no. 1, pp. 145- 151, 2020/01/01 2020, doi:10.1080/14756366.2019.1690480.
17. F. Chen et al, ̎In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds,” Journal of clinical virology, vol. 31,no.1, pp.69-75,2004/09/01/2004,
18. S. Jo, S. Kim, D. H. Shin, and M.-S. Kim, ̎Inhibition of SARS-CoV 3VL, protease by flavonoids,” Journal of Enzyme Inhibition and and Medicinal Chemistry, vol.35, no. 1, pp. 145- 151, 2020/01/01 2020, doi:10.1080/14756366.2019.1690480.
19. C-30 Endopeptidases Wikipedia.
20. K.-C. Chou, D.-Q. Wei, and W.-Z. Zhong, ̎Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS,” Biochemical and biophysical research communications, vol. 308, no.l, pp. 148-151,2003.
21. Michal acceptor Pubmedncbinlmgov.

Published

2020-08-15

How to Cite

Pawar, R. S., Dimri, M., & Maithani, A. (2020). Anti-COVID-19 natural products are spotlights for drug discovery and development. Asian Journal of Pharmaceutical Research and Development, 8(4), 88–90. https://doi.org/10.22270/ajprd.v8i4.785

Most read articles by the same author(s)

1 2 > >>