Characterization and Anti-Inflammatory Activity of Ethanol Extract of Sikkam (Bischofia Javanica Blume) Stem Bark
One of the medicinal plants that have been known since ancient times is sikkam (Bischofia javanica Blume) which is used as a natural dye in rattan and bamboo matting. Lawang Agung Village Community Kab. Lahat South Sumatra uses sikkam as a spice in cooking which is believed to be anti-inflammatory. This study aimed to assess the anti-inflammatory activity of ethanol extract of sikkam stem bark (Bischofia Javanica Blume) to reduce the edema volume of male white rats induced by carrageenan 1% and also to determine the effective dose of extract to reduce the volume of rat foot edema.Ethanol extract of sikkam bark (Bischofia Javanica Blume) was obtained by maceration. Anti-inflammatory activity test was divided into 5 groups. Group I (negative control) was given 0.5% CMC, Group II (positive control) was given diclofenac sodium 2.25 mg /kgBW, while Group III, IV and V were given ethanol extracts of sikkam bark with doses of 50,100 and 200 mg/kgBW respectively. Each rat was induced by 1% carrageenan subplantar injection. Examination of anti-inflammatory effects was measured using a digital plethysmometer at 30 to 360 minutes. Data were analyzed statistically using ANOVA (analysis of variance). The results showed that negative controls did not show an anti-inflammatory effect that had a significant difference with the other treatment groups. In conclusion, the ethanol extract of sikkam bark (Bischofia Javanica Blume) has effective anti-inflammatory activity at a dose of 200 mg/kgBW.
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