The Comparison of Antibacterial Activities of Soursop Leaf (Annona muricata L.) and Basil Leaf (Ocimum americanum L.) Ethanolic Extracts on Gel Formulated Against Staphilococcus aureus and Propionibacterium acnes

  • Ismail Efendy Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.
  • Ruth Mayana Rumanti Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia.
  • Mutia Rimala Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia
  • Indra Ginting Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia
  • Yettrie Bess Congencya Simarmata Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.
  • Vivi Eulis Diana Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Abstract

Objectives: The purpose of this study was to determine antibacterial activity of Soursop leaf (Annona muricata L.) and Basil leaf (Ocimum americanum L.) ethanolic extract on gel formulated againts Staphilococcus aureus and Propionibacterium acnes.


Design: This study uses an experimental laboratory design. This research uses difusion method, the inhibitory comparison between positive and negative control performed. This study compared the antibacterial activity of two gels that have different active ingredients to the growth of skin bacteria, namely Staphilococcus aureus and Propionibacterium acnes.


Interventions: The sample used was two types of gels each containing Soursop leaf and basil leaf ethanol extract that  in various concentration of 5, 10 and 15%. As a comparison, Clindamycin gel concentration 1% was used. The distilled water was used as a negative control.


Main outcome measure: The results showed a significant difference in inhibition between the samples groups against negative controls. The inhiibitory zone diameter of soursop leaf in 5, 10, and 15% concentrations were 9.30+0.17, 10.37+0.63, and 12.27+0.27 mm in inhibiting the growth of Staphilococcus aureus, and 9.00+0.00, 10.40+0.20, and 12.07+0.13 mm in inhibiting Propionibacterium acne. The result of the basil gel were 10.37+0.82, 11.50+0.50 and 12.43+0.29 against Staphilococcus aureus and 10.90+0.38, 12.00+0.00 and 13.37+0.20 against Propionibacterium acnes.


Conclusion: The both gels containing soursop and basil leaves ethanol extract have good antibacterial activity.


 

Keywords: antibacterial activity, Annona muricata L.,Ocimum americanum L., Propionibacterium acnes, Staphilococcus aureus

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Author Biographies

Ismail Efendy, Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.

Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.

Ruth Mayana Rumanti, Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia.

Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia.

Mutia Rimala, Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Indra Ginting, Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Yettrie Bess Congencya Simarmata, Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.

Magister of Public Health Program, Faculty of Public Health, Institut Kesehatan Helvetia.

Vivi Eulis Diana, Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

Bachelor of Pharmacy Study Program, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia

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How to Cite
Efendy, I., Rumanti, R., Rimala, M., Ginting, I., Simarmata, Y. B., & Diana, V. ( ). The Comparison of Antibacterial Activities of Soursop Leaf (Annona muricata L.) and Basil Leaf (Ocimum americanum L.) Ethanolic Extracts on Gel Formulated Against Staphilococcus aureus and Propionibacterium acnes. Asian Journal of Pharmaceutical Research and Development, 8(4), 01-03. https://doi.org/https://doi.org/10.22270/ajprd.v8i4.770