Emulgel: A Topical Preparation
Emulgel is an emerging topical drug formulation which is becoming increasingly popular due to its advantages over the conventional topical preparations. The emulgel is a combination of an emulsion and a gel and thus has a dual release control system. Its biggest and most favorable advantage has been the ability to incorporate hydrophobic drugs, thus making it emerge as a more popular choice these days. The emulgel is also greaseless, transparent; it can be easily spread and removed, has a long shelf- life, is thixotropic and is also pleasant looking. The emulgel is turning out be a preferred choice for cosmetic and dermatological preparations and its use and application will accelerate in the coming future.
2. Kshirsagar N A, Drug Delivery Systems, Ind. J. Pharmacology. 2000; 32:S54- S61.
3. Rashmi M., ‘Topical gel: A review’, Pharmainfo.com, August vol. 2008.
4. Nayank SH, Nkhat PD, Yeole PG, the Indian Pharmacist.2004; 3(27):7-14.
5. Devada P, Jain A, Vyas N, Jain S, ‘Development of antifungal emulsion based gel for topical fungal infection’, Int J Pharm Res Dev.2011; 3(2):18-25.
6. McGrath JA, Eady R & Pope FM, ‘Chapter 3: Anatomy and Organization of human skin’, p 3.1 3.15.
7. K. Khademhosseini and U. Demirci Gels Handbook: Fundamentals, Properties and Applications, World Scientific Pub Co Inc, 2016.
8. Ferry, John D., ‘Viscoelastic Properties of Polymers’, New York: Wiley,1980.
9. Kumar L, Verma R., ‘In vitro evaluation of topical gel prepared using natural polymer’, International Journal of Drug Delivery.2010; 2:58-63.
10. Gennaro AR, ed. Remington: the Science and Practice of Pharmacy, Easton, Mack Publishing Company19th ed., 1995.
11. Rieger MM, Lachman L, Lieberman HA, Kanig JL, ‘The Theory and Practice of Industrial Pharmacy’, 3rd ed., PA Lea and Febiger, Philadelphia, pp.1986; 502-533.
12. Jain A, Deveda P, Vyas N, Chauhan J et al., ‘Development of Antifungal Emulsion Based Gel for Topical Fungal Infection(S),’ IJPRD. 2011; 2(12).
13. Bruton L, Keith P, Blumenthal D, Buxton Z., ‘Goodman & Gillman’s Manual of Pharmacology and Therapeutics,’ McGraw’s Hill, pp. 2008; 1086-1094.
14. KoheiKyuki, Tomohisa Shibuya, Kaito Tsurumi Hajime Fujimura, ‘AntiInflammatory effect of diclofenacsodium ointment (cream) in topical application’, by Japan J. Phamacol. 1983; 33:121-132.
15. Principle of Skin Theraphy, from Dermweb.com.
16. P. Utreja, S. Jain, A.K. Tiwary, ‘Localized delivery of paditaxel using elastic liposomes: formulation development and evaluation’, Drug Delivery. 2011; 367-376.
17. Bolognia, Jorizzo et al., Dermatology edition, 1st Edition, Annemarie Uliasz, Mark Lebwohl. Chapter 129, other topical medications.
18. Cecv G., ‘Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels,’ International journal of pharmaceutics, 2008.
19. Kanikkannan N, Kandimalla K, Lamba SS, Singh M, ‘Structure activity relationship of chemical penetration enhancers in transdermal drug delivery,’ Current med chem. 1999; 6:593-608.
20. Singh PB, Choudhary PK, ‘Penetration enhancers for transfer drug delivery of systemic agents’, J Pharm Res. 2007; 6:44-50.
21. Kalia YN, Guy RH, ‘Modeling transdermal drug release’, Adv. Drug Deliv. Rev. 2001; 48:159-72.
22. Ayub, CA, Gomes ADM, Lima MVC, et al, ‘Topical Delivery of Fluconazole: In Vitro Skin Penetration and Permeation Using Emulsions as Dosage Forms’, Drug. Dev. Ind. Pharm. 2007; 33:273- 280.
23. Gaur PK, Mishra S, Purohit S, Dave K., ‘Transdermal Drug Delivery System: A Review’, AJPCR. 2009; 2:14-20.
24. Subranayam N, Ghosal SK, Moulik SP, ‘Enhanced In Vitro Percutaneous Absorption and In Vivo Anti-Inflammatory Effect of a Selective Cyclooxygenase Inhibitor Using Microemulsion’, Drug Dev. and Industrial Pharm., 2005.
25. Pathan, I.B.; Setty, C.M., ‘Chemical penetration enhancers for transdermal drug delivery systems’, Trop J Pharm Res. 2009; 8:173-179.
26. Rashmi, MS., ‘Topical Gel: A Review’, Pharmainfo.net, 2008.
27. Djordjevic J, Michniak B, Uhrich, Kathryn E, AAPS PharmSciTech. 2003; 5(4):1-12.
28. Bonacucina G, Cespi M, Palmieri GF, ‘Characterization and Stability of Emulsion Gels Based on Acrylamide/Sodium AcryloyldimethylTaurate Copolymer’, AAPS PharmSciTech. 2009; 10(2):34-45.
29. Curr AEB., ‘Transdermal Drug Delivery: Penetration Enhancement Techniques’, Heather. Drug Delivery. 2005; 5(2):23-33.
30. Curr AEB., ‘Transdermal Drug Delivery: Penetration Enhancement Techniques’, Heather. Drug Delivery. 2005; 2:23-33.
31. Rutrer N., ‘Drug absorption through the skin: a mixed blessing’, Arch Dis Child. 1987; 62:220-221.
32. Zhang XL, Zhao R, Qian W., ‘Preparation of an emulgel for treatment of aphthous ulcer on the basis of carbomers’, Chinese Pharm. J. 1995; 30:417-418.
33. Mortazavi SA, Aboofazeli R., ‘An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam’, Iranian Journal of Pharmaceutical Research. 2003; 135-140.
34. Kumar, L.; Verma, R., Int. J Drug Delivery. 2010; 58-63.
35. Jacob SW, Francone CA., Structure and Function of Man, (2).
36. Swarbrick, J., Encyclopedia of pharmaceutical technology, 3rd ed., 1551.
37. Jain A, Gautam SP, Gupta, Jain S, ‘Development and characterization of Ketoconazole emulgel for topical drug delivery’, Der Pharmacia Sinica. 2010; 1(3):221- 231.
38. WB Saunders Co. Philadelphia. 1970; 55-60.
39. Gupta GD, Gound RS., ‘Release rate of nimesulide from different gellants’, Indian J Pharm Sci. 1999; 61(1):229-23.
40. Gondaliya DP and Pundarikakshudu K., Indian drugs.2002; 39:465-473.
41. Sanjay, Jain BD, Padsalg A, Patel K, Mokale V, ‘Formulation, development and evaluation of Fluconazole gel in various polymer bases’, Asian J Pharm. 2007; 1:63-68.
42. Patel RP, Patel G, Baria A., ‘Formulation and evaluation of transdermal patch of aceclofenac’, International Journal Drug Del. 2009; 1(3):41 – 51.
43. Chaudhari P, Ajab A, Malpure P, Kolsure P, Sanap D, ‘Development and in-vitro evaluation of thermo reversible nasal gel formulations of Rizatriptan benzoate’, Indian J Pharm Edu. Res.2009; 43:55-62.
44. Masmoudi H, Piccerelle P, Le Dréau Y, Kister J., ‘A rheological method to evaluate the physical stability of highly viscous pharmaceutical oil-in-water emulsions’, Pharm Res.s 2006; 23(8):1937–47.
45. Tadros TF, ‘Future developments in cosmetic formulations’, International Journal Cosmetic Sciences. 1992; 14(3):93- 111.
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