Evaluation of Anti-Oxidant and Anti-Pyretic Activity of Fruit of Garcenia Padunculata
Most of the synthetic drugs used at present as analgesic and anti-inflammatory agents cause many side effects and toxic effects. Many medicines of plant origin with analgesic and anti-inflammatory activity have been used since long time without adverse effects. The purpose of the study was to explore the anti-pyretic and anti-oxidant activity of fruits of Garcinia pedunculata. The fruit of G. pedunculatawas collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract shows the presence of carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after 1hours, 4 hours, 8 hours and 12 hours after giving the extract dose of 100mg/kg and200mg/kg body weight, and it was found to produce a significant reduce in fever. DPPH radical scavenging activity (In-vitro anti-oxidant activity of G. pedunculata) of methanolic extract shows 38.31 as IC50 (µg/ml) whereas Ascorbic acid as standard in the same concentration shows34.81 IC50 (µg/ml). The obtained result justified the traditional use of G. pedunculata as anti-pyretic and antioxidant purpose.
2. Kluger M.J, Fever, Role of pyrogens and cryogens. Physiological Revision, 1991; 71:93- 127.
3. Paarakh P.M, Nigella sativa Linn. – A comprehensive review. Indian Journal of Natural Products and Resources, 2010; 1(4):409-429.
4. Huang D.J, Chen H.J, Lin C.D, & Lin Y.H, Antioxidant and ant proliferative activities of water spinach (Ipomea aquatica Frosk.) constituents. Botanical Bulletin Academia Sin, 2005; 406:99-106.
5. Rice-Evans C.A, Miller N.J, & Bolwell P.G, The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radical Research, 1995; 22(4):375–383.
6. Gerber M, Boutron-Ruault M.C, Hercberg C, & Riboli E, Food and cancer: state of the art about the protective effect of fruits and vegetables. Bulletindu Cancer, 2002; 89(3):293-312.
7. Sharma B.D, Sanjappa M, Flora of India. Botanical Survey of India, Calcutta. Edinb. Journal of Botany 1993; 3:98-131.
8. Kar A, Borkakoti S, & Borthakur S.K, Extended distribution of the genus Garcinia L. in sonitpur district, Assam, India. East Himalayan society for Spermatophyte taxonomy, 2008; 2(2):165-170.
9. Iinuma M, Tosha H, & Tanaka T, antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus. Biological and pharmaceutical bulletin, 1996; 19:311-314.
10. Sen S, Dey B, & Chakraborty R, Total phenolic, total flvonoid content, and antioxidant activity of leaves of Megna spinosa Roxb, an Indian medicinal plant. Chinese journal of natural medicine, 2013; 11(2):0149-0175.
11. Jamuna S, Paulsamy S & Karthika K, Screening of in vitro antioxidant activity of methanolic leaf and root extracts of Hypochaeris radicata L. (Asteraceae). Journal of Applied Pharmaceutical Science, 2012; 02(07):149-154.
12. Adams S.S, Hebborn P & Nicholson J.S, Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent. Journal of Pharm. Pharmac., 1968; 20:305-312.
13. Vogel G.H, Drug Discovery and Evaluation Pharmacological Assays. 2nd edition New York: Springer; 2002. 716.
14. Gangwar M, Gautam M.K, & Sharma A.K, Antioxidant Capacity and Radical Scavenging Effect of Polyphenol Rich Mallotus philippenensis Fruit Extract on Human Erythrocytes: An In Vitro Study. Hindawi publishing corporation scientiﬁc world journal, 2014; 12.
15. Mutalik S, Paridhavi K, & Udupa N, Antipyretic and analgesic effect of Solanum melongena. Indian Journal of Pharmacology, 2003; 35:312-5.
16. Jamuna S, Paulsamy S & Karthika K, Screening of in vitro antioxidant activity of methanolic leaf and root extracts of Hypochaeris radicata L. (Asteraceae). Journal of Applied Pharmaceutical Science, 2012; 02(07):149-154.
17. Rekka E & Kourounakis P.N, Effect of hydroxyethyl rutenosides and related compounds on lipid peroxidation and free radical scavenging activity-some structural aspects. Journal of Pharmacy and Pharmacology, 1991; 43:486-491.
18. Goswami P, Pharmacognostical, phytochemical and anthelmentic activity of polygonum muricatum. Journal of applied pharmaceutical science, 2018; 6(3):07-12.
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