Burn Wound Healing Activity of Ethanolic Extract of Acalypha indica in Oinment Formulated against Rabbits (Ocyctagus caniculus)

  • Khairani Fitri Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia
  • Tetty Noverita Khairani Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia
  • Fajar Apollo Sinaga Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia
  • Amenia Gracia Talunohi Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Abstract

Objectives: The purpose of this study was to determine burn wound healing activity of Acalypha indica L. in oinment formulated.


Design: This study uses an experimental laboratory design. This study used rabbits as test animals induced by burns with hot iron plates on the back. Extract ointment applied to the wound then observed the development of healing.


Interventions: The extract was formulated in ointments with concentrations of 3, 5 and 7%. positive control used was ointment containing sesame oil and negative control used is an ointment base.


Main outcome measure: The results showed a concentration of 3% had a slow and low effect, at a concentration of 5% it had a moderate healing phase, and a concentration of 7% had a good healing phase.


Conclusion: The ointments containing Acalypha indica leaf extracts have good activity in healing burns in rabbits.


 


 

Keywords: Acalypha indica L., ethanolic extract, oinment, wound healing.

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Author Biographies

Khairani Fitri, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Tetty Noverita Khairani, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Fajar Apollo Sinaga, Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia

Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia

Amenia Gracia Talunohi, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

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How to Cite
Fitri, K., Khairani, T., Sinaga, F., & Talunohi, A. (2020). Burn Wound Healing Activity of Ethanolic Extract of Acalypha indica in Oinment Formulated against Rabbits (Ocyctagus caniculus). Asian Journal of Pharmaceutical Research and Development, 8(3), 18-20. https://doi.org/https://doi.org/10.22270/ajprd.v8i3.740