Formulation, Characterization and Antioxidant Myricetin Nanophytosome for Topical Delivery

  • Purnamasari Nur Aini Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia
  • Dzakwan Muhammad Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia
  • Pramukantoro Ganet Eko School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia
  • Mauludin Rachmat School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia
  • El Fahmi School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

Abstract

Background: Phytosomes are recently introduced drug delivery system and novel botanical formulation to produce lipophilic molecular complex to improve absorption and bioavailability of phytoconstituent. Myricetin is a well-known flavonoid with different biological effects and contributed in food preserving by free radical scavenging activity. However, bioavailability of myricetin is an important limiting factor for its antioxidant activities.


Purpose: To overcome this limitation, in the present study we aimed to produce myricetin-loaded nano phytosomes to improve its physicochemical stability and bioavailability.


Methods: myricetin-loaded nano phytosome was prepared by using phosphatidylcholine (PC) and cholesterol (CH). Myricetin nanophytosomes system was characterized by particle size analyzer, particle size distribution (PDI), encapsulation efficiency and potential antioxidant activity.


Results: Results showed that formulation with the myricetin: PC: CH molar ratio of 1: 2: 0.8 had lower particle size (291.11 nm) and higher encapsulation efficiency percent (93%). Morphology analysis showed that myricetin nanophytosome spherical shape. The potential antioxidant data showed that incorporation myricetin in the phospholipid myricetin remained unchanged even after encapsulation of myricetin in binarynanophytosome formulation.


Conclusion: Nano phytosomal formulation of myricetin showed promising potential in fortification of nutraceutical with water insoluble antioxidants.


 

Keywords: Nanophytosome, Formulation, Myricetin, Antioxidant, Topical Delivery

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Author Biographies

Purnamasari Nur Aini, Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Dzakwan Muhammad, Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Pramukantoro Ganet Eko, School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

Mauludin Rachmat, School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

El Fahmi, School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

School of Pharmacy, Institute Technology Bandung Labtek VII Ganesha 10 Bandung , Indonesia

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How to Cite
Aini, P., Muhammad, D., Eko, P., Rachmat, M., & Fahmi, E. (2020). Formulation, Characterization and Antioxidant Myricetin Nanophytosome for Topical Delivery. Asian Journal of Pharmaceutical Research and Development, 8(3), 9-13. https://doi.org/https://doi.org/10.22270/ajprd.v8i3.718