Detection of Impurities in Bulk Drug and Capsule of Fluconazole

  • Uttam Kumar Sarker Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.
  • Md. Mahasin Ali Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.
  • Fatiha Farhana Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh
  • Md. Atikul Islam Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.
  • Shifat Kaisar Biochemist, Department of Biochemistry, Khwaja Yunus Ali Medical College and  Hospital, Enayetpur, Sirajgonj, Bangladesh.
  • Mir Misbahuddin Department of Pharmacology, Faculty of Basic Science, Bangabandhu Sheikh Mujib  Medical University, Shahbag, Dhaka, Bangladesh.
  • Md. Rabiul Islam Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.
  • Md. Elias Molla Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.

Abstract

Objectives: The purpose of this study was to identify the impurities and their amounts in the fluconazole bulk drug and capsule FLUNACTM (150 mg). Method: HPLC with diode array detector was used to carry out the study. The composition of mobile phase was acetonitrile: water (85:15 %) with flow rate of 0.7 mL/min and detected at 260 ± 1 nm. Results: Two impurities (one is known impurity A and other unknown impurity) were detected in the bulk drug and also in capsule FLUNAC (150mg). The total amount of impurities in fluconazole bulk drug and capsule were 0.368% and 0.392% respectively. Conclusion: The total amount of impurities was less than 1% which is acceptable. 

Keywords: Fluconazole, Impurities, HPLC.

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Author Biographies

Uttam Kumar Sarker, Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Md. Mahasin Ali, Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Fatiha Farhana, Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh

Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh

Md. Atikul Islam, Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Department of Chemistry, Faculty of Science, Hajee Mohammad Danesh Science and  Technology University, Dinajpur-5200, Bangladesh.

Shifat Kaisar, Biochemist, Department of Biochemistry, Khwaja Yunus Ali Medical College and  Hospital, Enayetpur, Sirajgonj, Bangladesh.

Biochemist, Department of Biochemistry, Khwaja Yunus Ali Medical College and  Hospital, Enayetpur, Sirajgonj, Bangladesh.

Mir Misbahuddin, Department of Pharmacology, Faculty of Basic Science, Bangabandhu Sheikh Mujib  Medical University, Shahbag, Dhaka, Bangladesh.

Department of Pharmacology, Faculty of Basic Science, Bangabandhu Sheikh Mujib  Medical University, Shahbag, Dhaka, Bangladesh.

Md. Rabiul Islam, Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.

Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.

Md. Elias Molla, Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.

Department of Chemistry, Faculty of Science, Jahangirnagar University, Savar, Dhaka,  Bangladesh.

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How to Cite
Sarker, U., Ali, M., Farhana, F., Islam, M., Kaisar, S., Misbahuddin, M., Islam, M., & Molla, M. (2020). Detection of Impurities in Bulk Drug and Capsule of Fluconazole. Asian Journal of Pharmaceutical Research and Development, 8(3), 14-17. https://doi.org/https://doi.org/10.22270/ajprd.v8i3.717