A Review on Validation of RP-HPLC Method for the Simultaneous Estimation

  • Rakesh Kumar Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Mukesh Bansal Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Dilip Agarwal Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Abstract

The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs. The review highlights a variety of analytical techniques such as titrimetric, chromatographic, spectroscopic, electrophoretic, and electrochemical and their corresponding methods that have been applied in the analysis of pharmaceuticals.


 


 

Keywords: Chromatographic, HPLC, Analytical Techniques.

Downloads

Download data is not yet available.

Author Biographies

Rakesh Kumar, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mukesh Bansal, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Dilip Agarwal, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

References

1. Sethi PD. Quantitative Analysis of Drugs in Pharmaceutical Formulations. 3rd edn., CBS Publishers and Distributors: New Delhi; 1997; 216-217.
2. Douglas A Skoog, Donald M West, James F Holler, Stanley R Crouch. Fundamentals of Analytical Chemistry. 8th edn., Thomson Asia Pvt. Ltd: Singapore.2007; 4:921, 975.
3. Sharma BK. 2002. Instrumental Methods of Chemical Analysis. 22nd edn., Krishna prakshan Media Pvt. Ltd: Meerut; C-9, C-292, C-295.
4. Jeffery GH, Bassett J, Mondham J, Denney RC. 1989, Singapore; 5, 216-217., Hobart H Willard, Lynne L Merritt, Jr., John A Dean, Frank A Settle, Jr. 1986. Instrumental
5. Methods of Analysis. 7th edn., CBS Publishers and Distributors: New Delhi; 1, 592, 622-628.
6. International Conference on Harmonization, "Q2A: Text on Validation of Analytical Procedures," Federal Register 1995; 60(40):11260–11262.
7. Lloyd R Slyder, Joseph J Kirkland, Joseph L Glajch. Practical HPLC Method Development. 2nd edn. John Wiley and Sons, Inc., USA; 1997; 22-24, 42, 235-24.
8. Anonymous. www.ich.org.
9. ICH Harmonized Tripartite Guidelines, Text on Bioanalytical Method Validation of : Text and Methodology. M10.
10. The United States of Pharmacopeia. 1995. 23/NF, 18, United States of Pharmacopeial Convention, inc., Rock Ville, MD., 1063,1961, 1988, 1990.
11. Gupta SC, Kapoor VK. Fundamentals of Mathematical Statistics. 9th edn. Sultan Chand and Sons: New Delhi;1996; 2.6, 3.2-3.28.
12. FDA Guidance for industry, Analytical procedures and method validation (draft guidance), August 2000.
13. Szepesi G, 1989 Selection of High performance chromatographic methods in pharmaceutical analysis. J. Chromatograph.1989; 464:265-278.
Statistics
27 Views | 42 Downloads
How to Cite
Kumar, R., Bansal, M., & Agarwal, D. (2020). A Review on Validation of RP-HPLC Method for the Simultaneous Estimation. Asian Journal of Pharmaceutical Research and Development, 8(4), 160-172. https://doi.org/https://doi.org/10.22270/ajprd.v8i4.692