Colon-Targeted Oral Drug Delivery Systems: A Review
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process. New systems and technologies have been developed for colon targeting and to overcome pervious method’s limitations. Colon targeting holds a great potential and still need more innovative work. This review article discusses, in brief, introduction of colon, factor effecting colonic transition, colonic diseases and the novel and emerging technologies for colon targeting.
2. Leuva VR, Patel BG, Chaudhary DJ, Patel JN, Modasiya MMK. Oral colon-specific drug delivery system. J Pharm Res. 2012; 5(4):2293–7.
3. Kumar M, Ali A, Kaldhone P, Shirode A, Kadam VJ. Report on pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Res. 2010; 3(3).
4. Philip AK, Philip B. Colon ta rgeted drug delivery systems: a review on primary and novel approaches. Oman Med J. 2010; 25(2):79–87.
5. Patel, A., Bhatt, N., Patel, K.R., Patel, N.M., and Patel, M.R.Colon Targeted Drug Delivery System: A Review System, Journal of Pharmaceutical Science And Bioscientific Research, 2011; 1(1):37-49.
6. Patel, N.R., Patel, D.A., Bharadia, P.D., Pandya, V. And Modi, D. Microsphere As A Novel Drug Delivery, International Journal Of Pharmacy And Life Sciences,2011; 2(8):992-997
7. Philip, A.K. And Philip, B.Colon Targeted Drug Delivery System: A Reveiw on Primary And Novel Approaches, Oman Medical Journal, 2010; 25(2):79-87.
8. Challa T, Vynala V and Allam KV: Colon-specific drug delivery systems: primary and novel approaches. International Journal of Pharmaceutical Sciences Review and Research 2011; 7(2):171-181.
9. 13. Wasnik S and Parmar P: The design of colon-specific drug delivery system and different approaches to treat colon disease. International Journal of Pharmaceutical Sciences Review and Research 2011; 6(2):167-177.
10. 14. Satpute CS, Pagare PK, Jadhav VM and Kadam VJ: Potential approaches of colon targeted drug delivery system. American Journal of Pharma Tech Research 2012; 2(4):311-328.
11. 15. Philip AK and Philip B: Colon targeted drug delivery systems: Primary and novel approaches. Oman Medical J 2010; 25(2):79-87.
16. Kotla NG, Gulati M, Singh SK and Shivapooja A: Facts, fallacies, and future of dissolution testing of polysaccharide-based colon-specific drug delivery. J Controlled Release 2014; 178:55-62.
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