An Updated Review on Pharmacology and Toxicities Related to Chloramphenicol
Chloramphenicol is a antimicrobial drug primarily its bacteriostatic, though at high concentration it shows bactericidal actions on some bacteria e.g. H. Influenzae. Initially chloramphenicol is obtained from sterptomycesvenezuelae in 1947, now its synthesized chemically and all the commercial product is synthetic. Chloramphenicol displays a broad-spectrum bacteriostatic activity by specifically inhibiting the bacterial proteinsynthesis. In certain but important cases, it also exhibits bactericidal activity, namely against thethree most common causes of meningitis, Haemophilusinfluenzae, Streptococcus pneumoniae andNeisseria meningitidis. Resistance to Chloramphenicol has been frequently reported and ascribed to a variety ofmechanisms. However, the most important concerns that limit its clinical utility relate to side effectssuch as neurotoxicity and hematologic disorders. In this review, we present previous and current research on Chloramphenicol and its derivatives with improved pharmacological properties.
2. Turton J.A., Yallop D., Andrews M., Fagg R., York M., Williams T.C., .Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Human and ExperimentalToxicology, 1999; 18:566-576.
3. Braja G Hazra, Vandana S. Pore &Shailaja P. Maybhate Synthesis of Chloramphenicol via a new Intermediate 4-para-Nitrophenyl-5-formamido-1,3-dioxane, Synthetic Communications, 1997; 27:11, 1857-1864.
4. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics, Page. No. 615-655.
5. K.D.Tripathi. Essentials of Medical Pharmacology, JAYPEE Brothers Medical
6. Publishers (P) Ltd, New Delhi 6 th Edition Page. No. 710-735.
7. Cravedi, J. P., Perdu-Durand, E., Baradat, M., Alary, J., Debrauwer, L., &Bories, G. (1995). Chloramphenicol Oxamylethanolamine as an End Product of Chloramphenicol Metabolism in Rat and Humans: Evidence for the Formation of a Phospholipid Adduct. Chemical Research in Toxicology,1995; 8(5):642–648.
8. Balbi, H. J. (2004). Chloramphenicol: a review. Pediatrics Rev. 25, 284–288.3
9. GC Oong and P Tadi.(2020). https://www.ncbi.nlm.nih.gov/books/NBK555966/
10. Yunis A.A, Smith U.S. and Restrepo (1970). Reversible Bone marrow suspension from Chloramphenicol: A consequence of mitochondrial injury. Archives of Internal Medicine,1970; 126(2):272-275.
11. Effiong G.S., Ebong P.E., Eyong E.U., Uwah A.J., Ekong U.E.,(2010).Amelioration of Chloramphenicol induced toxicity in rats by coconut water. Journal of Applied Sciences Research, 2010; 6(4):331-335.
12. Yuan ZR.,& Shi, Y. (2008). Chloramphenicol Induces Abnormal Differentiation and Inhibits Apoptosis in Activated T Cells. Cancer Research,2008; 68(12),4875–4881. doi:10.1158/0008-5472.can-07-6061.
13. Young N.S., Alter B.P., (1994). Aplastic Anemia. Journal of the American Medical Association, 208: 2045-2050.
14. Ballantyne B., Marrs T., Turner P., (1993). General and Applied Toxicology, Macmillan Press Ltd, pp. 267-292.
15. SuhrlandL.G., and Weisberger A.S. (1963). Chloramphenicol toxicity in liver and renal disease Archives of Internal Medicine, 112 (5):747-754.
16. Yunis, A.A., (1988) Chloramphenicol: Relation of structure to activity and toxicity. Annual Review of Pharmacology and Toxicology, 28: 83-100.
17. Yunis A.A., ArimuraG.k.,Isildar M.,DNA damage induced by Chloramphenicol and its nitroso derivative: Damage in intact cells. American Journal of Hematology, 2006; 24(1):77-84.
18. Dinos, G., Athanassopoulos, C., Missiri, D., Giannopoulou, P., Vlachogiannis, I., Papadopoulos, G., Kalpaxis, D. (2016). Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions. Antibiotics, 2016; 5(2):20.
19. Patil N. and Mule P.Sensitivity Pattern of Salmonella typhi And Para typhi A Isolates To Chloramphenicol And Other Anti-Typhoid Drugs: An In Vitro Study. Infection and Drug Resistance,2019; 12:3217–25.
20. Shen, A. Y., Haddad, E. J., Hunter-Smith, D. J., &Rozen, W. M. (2018). Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: a systematic review. ANZ Journal of Surgery.
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