Bioavailability Enhancement Techniques for Poorly Soluble Drugs: A Review

  • Ravi Gupta Kota College of Pharmacy, Kota, Rajasthan, India
  • Vidhi Jain Kota College of Pharmacy, Kota, Rajasthan, India
  • Jagdish Chand Nagar Kota College of Pharmacy, Kota, Rajasthan, India
  • Aadil Ansari Kota College of Pharmacy, Kota, Rajasthan, India
  • Kapil Sharma Kota College of Pharmacy, Kota, Rajasthan, India
  • Amrito Sarkar Kota College of Pharmacy, Kota, Rajasthan, India
  • Mohd. Shahid Khan Maharishi Arvind International Institute of Pharmacy, Kota

Abstract

Bioavailability is defined as the rate and extent of absorption of unchanged drug from its dosage form. The oral bioavailability of drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Low aqueous solubility is the major problem encountered with formulation development of new drugs. The article briefly highlights traditional and novel techniques that are used for solubility enhancement of BCS Class II drugs are discussed in this article. The Traditional techniques include use of co-solvents, hydrotrophy, micronization, change in dielectric constant of solvent, amorphous forms, chemical modification of drug, use of surfactants etc. Novel technologies are size reduction technologies, lipid based delivery system, micellar technologies, solid dispersion and many more.


 


 

Keywords: Bioavailability; Micronization; BCS; Solid dispersion.

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Author Biographies

Ravi Gupta, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Vidhi Jain, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Jagdish Chand Nagar, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Aadil Ansari, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Kapil Sharma, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Amrito Sarkar, Kota College of Pharmacy, Kota, Rajasthan, India

Kota College of Pharmacy, Kota, Rajasthan, India

Mohd. Shahid Khan, Maharishi Arvind International Institute of Pharmacy, Kota

Maharishi Arvind International Institute of Pharmacy, Kota

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How to Cite
Gupta, R., Jain, V., Nagar, J., Ansari, A., Sharma, K., Sarkar, A., & Khan, M. (2020). Bioavailability Enhancement Techniques for Poorly Soluble Drugs: A Review. Asian Journal of Pharmaceutical Research and Development, 8(2), 75-78. https://doi.org/https://doi.org/10.22270/ajprd.v8i2.664