Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion
Objectives: To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.
Interventions: Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.
Main outcomes measure: The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.
Conclusion: There was no significant cumulative percent drug release difference (p> 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.
2. Kumar, P, Singh, C. A Study on Solubility Enhancement Methods for Poorly Water Soluble Drugs. American Journal of Pharmacological Sciences. 2013; 1(4):67-73.
3. Zaini, E., MD Octavia, KR Wirza. Studi Sistem Dispersi Padat Meloksikam Menggunakan Hidroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS). Jurnal Farmasi Higea. 2017; 4(2):52-73.
4. Sunder, S., Nair R. Methods of Nanonization of Drugs for Enhancing their Dissolution. Eur.J. Adv.Eng.Tech.2016; 3(8):101-110.
5. Wilczewska, AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles as Drug Delivery System. Pharmacological Reports. 2012; 64(5):1020-1037.
6. Junghanns, JUAH, RH Muller. Nanocrystal Technology, Drug Delivery and Clinical Applications. Int J Nanomedicine. 2008; 3(3):295-310.
7. Bhowmik, D, Duraivel GHS, Kumar BP, Raghuvanshi V, Kumar KPS. Solid Dispersion- A Approach To Enhance The Dissolution Rate of Poorly Water Soluble Drugs.The Pharma Innovation-Journal. 2013; 1(12):24-38.
8. Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: importance and enhancement techniques. ISRN Pharm. 20122; 1:1-10.
9. Ramteke, KH, Dighe PA, Kharat AR, Patil SV. Mathematical Models of Drug Dissolution : A Review. Sch. Acad. J. Pharm. 2014; 3(5):388-396.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).