Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion

  • Nurul Karima Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia
  • Sumaiyah Sumaiyah Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia
  • Azizah Nasution Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

Abstract

Objectives: To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.


Interventions: Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.


Main outcomes measure: The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.


Conclusion: There was no significant cumulative percent drug release difference (p> 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.


 


 

Keywords: dissolution, griseofulvin, nano particle, solid dispersion.

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Author Biographies

Nurul Karima, Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Sumaiyah Sumaiyah, Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Azizah Nasution, Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

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How to Cite
Karima, N., Sumaiyah, S., & Nasution, A. (2020). Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion. Asian Journal of Pharmaceutical Research and Development, 8(1), 11-13. https://doi.org/https://doi.org/10.22270/ajprd.v8i1.644