Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion
DOI:
https://doi.org/10.22270/ajprd.v8i1.644Keywords:
dissolution, griseofulvin, nano particle, solid dispersion.Abstract
Objectives: To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.
Interventions: Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.
Main outcomes measure: The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.
Conclusion: There was no significant cumulative percent drug release difference (p> 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.
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2. Kumar, P, Singh, C. A Study on Solubility Enhancement Methods for Poorly Water Soluble Drugs. American Journal of Pharmacological Sciences. 2013; 1(4):67-73.
3. Zaini, E., MD Octavia, KR Wirza. Studi Sistem Dispersi Padat Meloksikam Menggunakan Hidroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS). Jurnal Farmasi Higea. 2017; 4(2):52-73.
4. Sunder, S., Nair R. Methods of Nanonization of Drugs for Enhancing their Dissolution. Eur.J. Adv.Eng.Tech.2016; 3(8):101-110.
5. Wilczewska, AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles as Drug Delivery System. Pharmacological Reports. 2012; 64(5):1020-1037.
6. Junghanns, JUAH, RH Muller. Nanocrystal Technology, Drug Delivery and Clinical Applications. Int J Nanomedicine. 2008; 3(3):295-310.
7. Bhowmik, D, Duraivel GHS, Kumar BP, Raghuvanshi V, Kumar KPS. Solid Dispersion- A Approach To Enhance The Dissolution Rate of Poorly Water Soluble Drugs.The Pharma Innovation-Journal. 2013; 1(12):24-38.
8. Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: importance and enhancement techniques. ISRN Pharm. 20122; 1:1-10.
9. Ramteke, KH, Dighe PA, Kharat AR, Patil SV. Mathematical Models of Drug Dissolution : A Review. Sch. Acad. J. Pharm. 2014; 3(5):388-396.
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