Phytochemicals Analysis and Cytotoxicity Activity of Ethanol Extract of Litseacubeba Lour.Heartwood

Authors

  • Fujiko M Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,
  • Dalimunthe A Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,
  • Masfria M Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

DOI:

https://doi.org/10.22270/ajprd.v8i1.643

Keywords:

heartwood, Litseacubeba Lour, T47D cell, cytotoxicity, phytochemicals.

Abstract

 

Objective: The purpose of this study was to determine the chemical compounds whichcontained in the ethanol extract and cytotoxic activity ethanol extract of Litseacubeba heartwood induced in T47D cells.

Methods: The ethanol extract was extracted by maceration using ethanol 96% solvent. Cytotoxic activity was determined with MTT method and the IC50analyzed using SPSS 23.

Results: Phytochemicals screening were showed that the ethanol extract of Litseacubeba heartwood contained steroids/triterpenoids, glycosides, alkaloids, flavonoids, saponins and tannins. The IC50of ethanol extract of Litseacubeba heartwood were 349,57 ±0,35μg/ml in T47D cells.

Conclusions: Ethanol extract of Litseacubeba heartwood has activity as an anticancer to T47D cells breast cancer agents.

 

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Author Biographies

Fujiko M, Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,

Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,

Dalimunthe A, Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,

Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia,

Masfria M, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155,  Indonesia

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Published

2020-02-15

How to Cite

M, F., A, D., & M, M. (2020). Phytochemicals Analysis and Cytotoxicity Activity of Ethanol Extract of Litseacubeba Lour.Heartwood. Asian Journal of Pharmaceutical Research and Development, 8(1), 14–17. https://doi.org/10.22270/ajprd.v8i1.643

Issue

Vol. 8 No. 1 (2020): Vol 8 No 1 (2020): Volume 8 Issue 1 Jan - Feb. 2020

Section

Research Articles

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