Assessment of Drug Related Problems among Type 2 Diabetes Mellitus Patients with Hypertension in Doloksanggul Hospital, North Sumatera: A Retro prospective Study
Objective: The aim of this study was to assess the drug-related problems (DRPs) in Type 2 diabetes mellitus(T2DM) patients whom also diagnosed with hypertension. Methods: The retrospective study was conducted from October to December 2018 at Doloksanggul Hospital in North Sumatera, Indonesia involving 42 T2DM with hypertension patients according to research inclusion criteria. The assessment of DRPs was based on the Pharmaceutical Care Network Europe (PCNE) tools version 8.01. Results: This study identified 41 DRPs, averaging 0.98±0.24 DRPs per patient. The majority of problems were treatment effectiveness problems 97.62% (41 patients) while the patient related was the main causes (47.24%). The most intervention was conducted at patient level (71.62%).Conclusion: Early detection of DRPs by pharmacist are essential to prevent DRPs and to ensure the effectiveness of drug therapy.
2. Zazuli, Z., Rohaya, A., and Adnyana, I.K. Drug-Related Problems in Type 2 Diabetic Patients with Hypertension: A Prospective Study. Journal of Basic and Clinical Pharmacy. 2017; 8(4):251-254.
3. Shrivastava,S.R.,Shrivastava, P.S., and Ramasamy, J.Role of Self-care in Management of Diabetes mellitus. Journal of Diabetes & Metabolic Disorders. 2013; 12:14.
4. Munger, M.A. Polypharmacy and Combination Therapy in The Management of Hypertension in Elderly Patients with Co-morbid Diabetes mellitus. Drug Aging. 2010; 27(11):871-883.
5. Pharmaceutical Care Network Europe Foundation. PCNE Classification for Drug-related Problems, V.8.01 2017.
6. U.K. Prospective Diabetes Study Group. Tight Blood Pressure Control and Risk of Macrovascular and Microvascular Complication in Type 2 Diabetes: UKPDS 38. BMJ. 1998; 317:703-713.
7. Ellis, S.L., Billups, S.J., Malone, D.C., Carter, B.L., Covery, D., and Mason, B., et al. Types of Interventions Made by Clinical Pharmacists in The IMPROVE Study. Impact of Managed Pharmaceutical Care on Resource Utilization and Outcomes in Veteran Affairs Medical Counters. Pharmacotherapy. 2000; 20:429-435.
8. Ayele, Y., Melaku, K., Dechasa, M., Ayalew, M.B., and Horsa, B.A. Assessment of Drug Related Problems Among Type 2 Diabetes mellitus Patients with Hypertension in HiwotFana Specialized University Hospital, Harar, Eastern Etiopia: BMC Res Notes. 2018; 11:728.
9. Zazuli, Z., Rohaya, A., andAdnyana, I.K.Drug Related Problems in Type 2 Diabetic Patients with Hypertension in Cimahi, West Jaya, Indonesia: A prospective Study. International Journal of Green Pharmacy. 2017;11(2):298
10. Kaufmann, C.P., Stampfli, D. Hersberger, K.F., and Schaefer, M.A.Determination of Risk Factors for Drug-Related Problems: A Multidisciplinary Triangulation Proses. BMJ Open. 2015; 5(3):e006376
11. PCNE. PCNE Clasification for Drug related Problems. V8.01. Pharmaceutical Care Network Europe Foundation.2017
12. Londhe, S.P.,Joseph, A., John, J., Philip, K., and Philip, L.To Identify, Evaluate, and Analyze Possible Drug-drug Interactions in Patients Diagnosed as Type 2 Diabetes mellitus with Hypertension in A Tertiary Care Teaching Hospital. Asian J Pharm Clin Res. 2015;8(6):169-174
13. Huri, H.Z. and Wee, H.F. Drug Related Problems in Type 2 Diabetes Patients with Hypertension: A Cross-sectialRetroprospective Study. BMC Endocrine Disorders. 2013; 13:2
14. Shareef, J., Fernandes, J.,and Samaga, L.N. Clinical pharmacist Interventions in Drug Therapy in Patients with Diabetes mellitus and Hypertension in A University Teaching Hospital. International Journal of Pharmaceutical Science and Research. 2018:27
15. Patney, V., Connell, A.W., and Bakris, G. Hypertension Management in Diabetic Kidney Disease. Diabetes Spectrum Journal. 2015; 28(3):175-180.
16. Elnaem, M.H., Nazar, N.I.M., Rahman, N.S.A., and Jamshed, S. Analysis of Drug-related Problems Identified by Future Pharmacists in Medical Wards of Tertiary Hospitals in the State of Pahang, Malaysia. J Young Pharm. 2019; 11(1):77-81
17. Mahwi, T.O. and Obied, K.A. Role of The Pharmaceutical Care in The Management of Patients with Type 2 Diabetes mellitus. IJPSR. 2013:4(4):1363-1369.
18. Ogbonna, B.O., Ezenduka, C.C., Opara, C.A., and Ahara, L.G. Drug Therapy Problems in Patients with Type-2 Diabetes in a Tertiary Hospital in Nigeria. IJIRD. 2014; 3(1):494-502.
19. Glasgow, R.E. and Strycker, L.A. Preventive Care Prcticeddor Diabetes Management in Two Primary Care Samples. Am J Prev Med.2002; 25(7):1159-1171.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).