A Review Article on Selective Serotonin Reuptake Inhibitors (SSRIS)

  • Devi Meena College of Pharmacy, Roorkee Uttarakhand, India
  • Subhash Subhash Chand College of Pharmacy, Roorkee Uttarakhand, India
  • Deovrat Kumar College of Pharmacy, Roorkee Uttarakhand, India


Depression, tension and mental health have been ignored as a serious issue since ages. Depression can be fatal or life-threatening, if not treated to this problem. Antidepressants are also regularly used to treat many other conditions, such as social phobia, fibromyalgia, panic disorder, anxiety/anxiety depression, PTSD, OCD, PMDD, and menopause. The major antidepressant used in the study followed oral prescribing trends. A “serious adverse reaction means an adverse reaction which is fatal, life-threatening, disabling, incapacitating, or which results in or prolongs hospitalization.” Material method collect from Google, Wikipedia, Elsevier, PubMed, Google scholar, Sci-Hub etc. This is a meta-analysis study. Fluoxetine have the longest half-life, but Fluvoxamine have short half-life. SSRIs increase the serum concentrations of the latter two drugs, potentiating their effects and increasing the risk of toxicity. Fluoxetine and Paroxetine specifically, are known to cause a 5-fold increase in serum TCA concentration upon co-administration. By in the addition of combination therapy SSRIs associated many types of adverse drug reaction and some time it can cause serotonin syndrome also.


Keywords: Depression, Antidepressants, Adverse drug reaction, Serotonin syndrome, Combination therapy.


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Author Biographies

Devi Meena, College of Pharmacy, Roorkee Uttarakhand, India

College of Pharmacy Roorkee, Uttarakhand, India

Subhash Subhash Chand, College of Pharmacy, Roorkee Uttarakhand, India

College of Pharmacy, Roorkee Uttarakhand, India

Deovrat Kumar, College of Pharmacy, Roorkee Uttarakhand, India

College of Pharmacy, Roorkee Uttarakhand, India


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How to Cite
Meena, D., Subhash Chand, S., & Kumar, D. (2019). A Review Article on Selective Serotonin Reuptake Inhibitors (SSRIS). Asian Journal of Pharmaceutical Research and Development, 7(6), 72-75. https://doi.org/https://doi.org/10.22270/ajprd.v7i6.592