To Study Chronic Toxicity for Polyherbal Formulation
The objective of the present study to investigate the safety of polyherbal formulation containing Tribulus terrestris, Withania somnifera and Chlorophytum borivilianum by determining its potential toxicity after chronic administration in rats as per OECD guideline No.421. Wistar rats (150-200g) in treatment group I, II and III received polyherbal formulation of 400 mg/kg/day, 800 mg/kg/day and 1600 mg/kg/day (p.o.) respectively for 90 days. After 90 days rats were decapitated and vital organs (brain, heart, kidney, liver, ovary, testis and epididymis) removed, weighed and made histological sections. Result showed no significant treatment-related changes in organ weights and absence of any disease state or lesions in histological sections of brain, heart, liver, kidney observed. But there were changes in weights and histoarchitectural changes (toxic effects) of ovary, testis and epididymis in group wise observed.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).